...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Development >Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl
【24h】

Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl

机译：结缔组织细胞参与肌肉活动，但不参与肌肉细胞的活动建立近端肢体再生

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

During salamander limb regeneration, only the structures distal to the amputation plane are regenerated, a property known as the rule of distal transformation. Multiple cell types are involved in limb regeneration; therefore, determining which cell types participate in distal transformation is important for understanding how the proximo-distal outcome of regeneration is achieved. We show that connective tissue-derived blastema cells obey the rule of distal transformation. They also have nuclear MEIS, which can act as an upper arm identity regulator, only upon upper arm amputation. By contrast, myogenic cells do not obey the rule of distal transformation and display nuclear MEIS upon amputation at any proximo-distal level. These results indicate that connective tissue cells, but not myogenic cells, are involved in establishing the proximo-distal outcome of regeneration and are likely to guide muscle patterning. Moreover, we show that, similarly to limb development, muscle patterning in regeneration is influenced by βcatenin signalling.
机译：在sal肢再生过程中，仅截肢平面远端的结构被再生，这种特性被称为远端转换的规则。肢体再生涉及多种细胞类型。因此，确定哪种细胞类型参与远端转化对于理解如何实现近端远端再生至关重要。我们显示结缔组织衍生的胚细胞遵守远端转化的规则。它们还具有核MEIS，仅在截肢时才可以充当上臂身份调节器。相反，成肌细胞不服从远侧转化的规则，并且在任何近端水平截肢时均显示出核MEIS。这些结果表明，结缔组织细胞而不是肌原细胞参与建立近端远端再生，并可能指导肌肉构图。此外，我们表明，与肢体发育相似，再生过程中的肌肉图案受β-catenin信号的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号