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Cell-autonomous and non-autonomous growth-defective mutants of Drosophila melanogaster.

机译：果蝇的细胞自主和非自主生长缺陷突变体。

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During animal development, growth of the various tissues and organs that make up the body must be coordinated. Despite recent progress in understanding growth control within the cell unit, the mechanisms that coordinate growth at the organismal level are still poorly understood. To study this problem, we performed a genetic screen for larval growth-defective mutants in Drosophila melanogaster. Characterization of these mutants revealed distinct types of larval growth defects. An allelic series for the translation initiation factor, Eif4A, showed different growth rates and suggests that Eif4A could be used as a dose-dependent growth regulator. Two mutants that fail to exit cellular quiescence at larval hatching (milou and eif4(1006)) have a DNA replication block that can be bypassed by overexpression of the E2F transcription factor. A mutation (bonsai) in a homolog of the prokaryotic ribosomal protein, RPS15, causes a growth defect that is non-cell-autonomous. Our results emphasize the importance of translational regulation for the exit from quiescence. They suggest that the level of protein synthesis required for cell cycle progression varies according to tissue type. The isolation of non-cell-autonomous larval growth-defective mutants suggests that specialized organs coordinate growth throughout the animal and provides new tools for studies of organismal growth regulation.
机译：在动物发育过程中，必须协调组成人体的各种组织和器官的生长。尽管最近在了解细胞单元内的生长控制方面取得了进展，但在生物水平上协调生长的机制仍知之甚少。为了研究这个问题，我们对果蝇的果蝇生长缺陷型突变体进行了遗传筛选。这些突变体的表征揭示了不同类型的幼虫生长缺陷。翻译起始因子Eif4A的等位基因系列显示出不同的生长速率，表明Eif4A可用作剂量依赖性生长调节剂。两个在幼虫孵化时未能退出细胞静止状态的突变体（milou和eif4（1006））具有一个DNA复制区，可以被E2F转录因子的过表达所绕过。 RPS15原核生物核糖体蛋白同源物中的突变（盆景）会导致非细胞自主的生长缺陷。我们的结果强调了翻译调节对于退出静态的重要性。他们建议细胞周期进程所需的蛋白质合成水平根据组织类型而异。非细胞自主幼虫生长缺陷型突变体的分离表明，专门的器官协调了整个动物的生长，并为研究生物生长调节提供了新的工具。

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