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首页> 外文期刊>Development >The sub-lip domain--a distinct pathway for myotome precursors that demonstrate rostral-caudal migration.
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The sub-lip domain--a distinct pathway for myotome precursors that demonstrate rostral-caudal migration.

机译：唇下结构域-肌动蛋白前体的独特途径，显示了尾状尾部迁移。

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摘要

We have previously reported that the myotome is formed by a first wave of pioneer cells generated from all along the dorsomedial portion of the epithelial somite and a second wave of cells issued from all four edges of the dermomyotome. Cells from the extreme rostral and caudal edges directly generate myofibers that elongate towards the opposite pole of each segment and along the pre-existing myotomal scaffold. In contrast, cells from the dorsomedial and ventrolateral lips first reach the extreme edges and then contribute to myofiber formation. The mechanism by which these epithelial cells translocate remained unknown and was the goal of the present study. We have found that epithelial cells along the dorsomedial and ventrolateral lips of the dermomyotome first delaminate into the immediate underlayer of the corresponding lips, the sub-lip domain, then migrate longitudinally along this pathway until reaching the extreme edges from which they differentiate into myofibers. Cells of the sub-lip domain are negative for Pax3 and desmin but express MyoD, Myf5 and FREK, suggesting that they are specific myogenic progenitors.
机译：我们以前曾报道过，肌节是由第一波先驱细胞形成的，第一波先驱细胞是由沿上皮卵石的背侧部分产生的，第二波细胞是由皮肤切开术的所有四个边缘发出的。来自极额鼻端和尾端边缘的细胞直接产生肌纤维，肌纤维向着每个节段的相反极并沿着预先存在的肌细胞支架延伸。相反，来自背部和腹外侧唇的细胞首先到达边缘，然后促成肌纤维形成。这些上皮细胞易位的机制仍然是未知的，并且是本研究的目标。我们已经发现，沿皮肌膜刀的背侧和腹侧唇的上皮细胞首先分层进入相应唇的直接下层，即唇下区域，然后沿该途径纵向迁移，直到到达其分化为肌纤维的最边缘。亚唇域的细胞对Pax3和desmin呈阴性，但表达MyoD，Myf5和FREK，表明它们是特定的成肌祖细胞。

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