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首页> 外文期刊>Development >Lobe and Serrate are required for cell survival during early eye development in Drosophila.
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Lobe and Serrate are required for cell survival during early eye development in Drosophila.

机译：果蝇早期眼睛发育期间细胞存活需要叶和锯齿。

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摘要

Organogenesis involves an initial surge of cell proliferation, leading to differentiation. This is followed by cell death in order to remove extra cells. During early development, there is little or no cell death. However, there is a lack of information concerning the genes required for survival during the early cell-proliferation phase. Here, we show that Lobe (L) and the Notch (N) ligand Serrate (Ser), which are both involved in ventral eye growth, are required for cell survival in the early eye disc. We observed that the loss-of-ventral-eye phenotype in L or Ser mutants is due to the induction of cell death and the upregulation of secreted Wingless (Wg). This loss-of-ventral-eye phenotype can be rescued by (i) increasing the levels of cell death inhibitors, (ii) reducing the levels of Hid-Reaper-Grim complex, or (iii) reducing canonical Wg signaling components. Blocking Jun-N-terminal kinase (JNK) signaling, which can induce caspase-independent cell death, significantly rescued ventral eye loss in Lor Ser mutants. However, blocking both caspase-dependent cell death and JNK signaling together showed stronger rescues of the L- or Ser-mutant eye at a 1.5-fold higher frequency. This suggests that L or Ser loss-of-function triggers both caspase-dependent and -independent cell death. Our studies thus identify a mechanism responsible for cell survival in the early eye.
机译：器官发生涉及细胞增殖的最初激增，导致分化。随后是细胞死亡，以去除多余的细胞。在早期发育期间，几乎没有细胞死亡。但是，缺乏关于早期细胞增殖阶段中存活所需基因的信息。在这里，我们显示了都参与腹侧眼部生长的叶（L）和缺口（N）配体锯齿（Ser），是早期眼球中细胞存活所必需的。我们观察到L或Ser突变体的腹侧眼表型丧失是由于细胞死亡的诱导和分泌的Wingless（Wg）的上调。可以通过（i）增加细胞死亡抑制剂的水平，（ii）降低Hid-Reaper-Grim复合物的水平，或（iii）减少经典的Wg信号传导成分来挽救这种丧失视力的眼表型。阻断Jun-N端激酶（JNK）信号传导可诱导caspase依赖性细胞死亡，可显着挽救Lor Ser突变体的腹侧眼损失。但是，同时阻断caspase依赖性细胞死亡和JNK信号传导，可以以1.5倍的较高频率对L或Ser突变体的眼睛进行更强的拯救。这表明L或Ser功能丧失触发胱天蛋白酶依赖性和非依赖性细胞死亡。因此，我们的研究确定了负责早期眼细胞存活的机制。

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