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首页> 外文期刊>Development >Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse.
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Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse.

机译：小鼠唾液腺和肾脏的导管成熟需要与粒头相关的转录因子。

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摘要

Duct epithelial structure is an essential feature of many internal organs, including exocrine glands and the kidney. The ducts not only mediate fluid transfer but also help to maintain homeostasis. For instance, fluids and solutes are resorbed from or secreted into the primary fluid flowing through the lumen of the ducts in the exocrine glands and kidneys. The molecular mechanism underlying the functional maturation of these ducts remains largely unknown. Here, we show that a grainyhead-related transcription factor, CP2-like 1 (CP2L1), is required for the maturation of the ducts of the salivary gland and kidney. In the mouse, Cp2l1 is specifically expressed in the developing ducts of a number of exocrine glands, including the salivary gland, as well as in those of the kidney. In Cp2l1-deficient mice, the expression of genes directly involved in functional maturation of the ducts was specifically reduced in both the salivary gland and kidney, indicating that Cp2l1 is required for the differentiation of duct cells. Furthermore, the composition of saliva and urine was abnormal in these mice. These results indicate that Cp2l1 expression is required for normal duct development in both the salivary gland and kidney.
机译：导管上皮结构是许多内部器官（包括外分泌腺和肾脏）的基本特征。这些导管不仅可以调节液体的传输，还有助于维持体内平衡。例如，流体和溶质从流经外分泌腺和肾脏的管腔的主要流体中吸收或分泌出来。这些管道的功能成熟的分子机制仍然是未知的。在这里，我们表明，唾液腺和肾脏的导管成熟需要与粒头相关的转录因子CP2样1（CP2L1）。在小鼠中，Cp21l在许多外分泌腺（包括唾液腺）和肾脏的发育管道中特异性表达。在Cp2l1缺陷型小鼠中，唾液腺和肾脏中都直接减少了直接参与导管功能成熟的基因的表达，这表明Cp21l是导管细胞分化所必需的。此外，这些小鼠的唾液和尿液成分异常。这些结果表明，唾液腺和肾脏中的正常导管发育都需要Cp2l1表达。

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