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首页> 外文期刊>Development >The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes.
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The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes.

机译:边界帽:神经c干细胞的来源,其产生多种感觉神经元亚型。

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摘要

The boundary cap (BC) is a transient neural crest-derived group of cells located at the dorsal root entry zone (DREZ) that have been shown to differentiate into sensory neurons and glia in vivo. We find that when placed in culture, BC cells self-renew, show multipotency in clonal cultures and express neural crest stem cell (NCSCs) markers. Unlike sciatic nerve NCSCs, the BC-NCSC (bNCSCs) generates sensory neurons upon differentiation. The bNCSCs constitute a common source of cells for functionally diverse types of neurons, as a single bNCSC can give rise to several types of nociceptive and thermoreceptive sensory neurons. Our data suggests that BC cells comprise a source of multipotent sensory specified stem cells that persist throughout embryogenesis.
机译:边界帽(BC)是位于背根进入区(DREZ)的瞬时神经c来源的细胞群,已被证明在体内可分化为感觉神经元和神经胶质。我们发现,放置在培养物中时,BC细胞会自我更新,在克隆培养物中显示多能性并表达神经c干细胞(NCSCs)标记。与坐骨神经NCSC不同,BC-NCSC(bNCSC)在分化时会产生感觉神经元。 bNCSC构成功能多样的神经元的细胞的共同来源,因为单个bNCSC可以产生几种伤害性和热感受性感觉神经元。我们的数据表明,BC细胞构成了在整个胚胎发生过程中持续存在的多能感觉特异干细胞的来源。

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