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首页> 外文期刊>Diabetes care >Cardiovascular characteristics in subjects with increasing levels of abnormal glucose regulation: The strong heart study
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Cardiovascular characteristics in subjects with increasing levels of abnormal glucose regulation: The strong heart study

机译：葡萄糖调节异常水平升高的受试者的心血管特征：强有力的心脏研究

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OBJECTIVE-To evaluate whether impaired fasting glucose (IFG) or the combination of IFG and impaired glucose tolerance (IGT) is associated with progressive abnormalities of cardiac geometry and function. RESEARCH DESIGN AND METHODS-We studied 562 nondiabetic (311 women), nonhypertensive participants of the second Strong Heart Study exam, without prevalent cardiovascular (CV) disease and with estimated glomerular filtration rate ??60 mL/min/1.73 m 2 (age 46-65 years, 198 with isolated IFG [35%], and 132 with combined IFG and IGT [23%]). Anthropometric parameters, insulin resistance, fibrinogen, C-reactive protein (CRP), lipid profile, blood pressure (BP), and echocardiographic parameters were compared with 232 participants with normal glucose tolerance (NGT). RESULTS-BMI, prevalence of central obesity, homeostaticmodel assessment index of insulin resistance, plasma triglycerides, fibrinogen, and CRP increased progressively across categories of glucose intolerance (P < 0.0001), with the IFG+IGT group having higher values than those with isolated IFG (0.05<P<0.0001). Compared withNGT, both IFG and IFG+IGT exhibited greater left ventricular (LV) mass (P < 0.0001) and lower Doppler early peak rapid filling velocity to peak atrial filling velocity ratio (P < 0.005), without differences in LV systolic function. The odds of LV hypertrophy (LV mass index >46.7 in women or >49.2 g/m2.7 in men) was 3.5 in IFG participants (95% CI 0.68-17.76; P = NS) and 9.76 (2.03-46.79; P = 0.004) in IFG+IGT, compared with NGT, after adjustment for age, sex, heart rate, systolic BP, and waist circumference (WC). In the overall sample, LV mass index was associated with WC (P = 0.033), CRP (P = 0.027), and 2-h oral glucose tolerance test (P = 0.001) independently of confounders. CONCLUSIONS-Cardiometabolic profile and markers of inflammation are more severely altered in men and women with both IFG and IGT compared with those with IFG alone. These individuals, in the absence of hypertension, have a 10-fold greater probability of preclinical CV disease (LV hypertrophy). ? 2013 by the American Diabetes Association.
机译：目的-评估空腹血糖受损（IFG）或IFG与葡萄糖耐量受损（IGT）的组合是否与心脏几何形状和功能的进行性异常相关。研究设计和方法-我们研究了562名非糖尿病（311名女性），第二次强心研究考试的非高血压参与者，无普遍的心血管（CV）疾病且估计肾小球滤过率≥60 mL / min / 1.73 m 2（46岁） -65岁，有IFG隔离的有198人[35％]，有IFG和IGT合并的有132人[23％]。将人体测量参数，胰岛素抵抗，纤维蛋白原，C反应蛋白（CRP），脂质分布，血压（BP）和超声心动图参数与232名葡萄糖耐量正常（NGT）的参与者进行了比较。结果-BMI，中枢性肥胖的患病率，胰岛素抵抗，血浆甘油三酸酯，纤维蛋白原和CRP的稳态模型评估指数在不同的葡萄糖耐量类别之间呈逐步上升趋势（P <0.0001），其中IFG + IGT组的值高于孤立IFG组（0.05

46.7或男性> 49.2 g / m2.7）的几率是3.5（95％CI 0.68-17.76; P = NS）和9.76（2.03-46.79; P =调整年龄，性别，心率，收缩压和腰围（WC）后，IFG + IGT与NGT相比为0.004）。在整个样本中，独立于混杂因素，LV质量指数与WC（P = 0.033），CRP（P = 0.027）和2小时口服葡萄糖耐量试验（P = 0.001）相关。结论与单独使用IFG的男性和女性相比，IFG和IGT的男性和女性的心血管代谢特征和炎症指标变化更为严重。这些个体在没有高血压的情况下发生临床前CV疾病（LV肥大）的可能性要高10倍。 ？ 2013年由美国糖尿病协会颁发。

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