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首页> 外文期刊>Diabetes care >Cardiac autonomic nervous dysfunction in diabetic patients with a mitochondrial DNA mutation: assessment by heart rate variability.
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Cardiac autonomic nervous dysfunction in diabetic patients with a mitochondrial DNA mutation: assessment by heart rate variability.

机译：患有线粒体DNA突变的糖尿病患者的心脏自主神经功能障碍：心率变异性评估。

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OBJECTIVE: To elucidate the degree and characteristics of cardiac autonomic nervous dysfunction in diabetic patients associated with a mitochondrial DNA mutation at base pair 3243. RESEARCH DESIGN AND METHODS: We investigated heart rate variability using 24-h Holter monitoring in 10 diabetic patients with the mutation compared with 55 ordinary diabetic patients and 45 nondiabetic control subjects. RESULTS: Age and sex were similar in the three groups. Between patients with the mutation and ordinary diabetic patients, the duration of diabetes and blood glycemic levels were not different. In the time domain analysis of heart rate variability, patients with the mutation and ordinary diabetic patients had significantly smaller SDNN index and pNN50 than control subjects. Compared with ordinary diabetic patients, patients with the mutation had smaller SDNN index (P < 0.02), but rMSSD and pNN50 were not different. In the frequency domain analysis, total, low frequency (LF), and high frequency (HF) spectra were significantly smaller in patients with the mutation and ordinary diabetic patients than in control subjects. Compared with ordinary diabetic patients, patients with the mutation had smaller total and LF spectra (P < 0.02). However, HF spectra were not significantly different. Notably, the LF/HF spectra ratio was lower in patients with the mutation than in ordinary diabetic patients and control subjects (P < 0.05), but this ratio was similar in ordinary diabetic patients and control subjects. CONCLUSIONS: Our results suggest that diabetic patients with the mitochondrial DNA mutation have more severely impaired cardiac autonomic nervous function with sympathovagal imbalance, as compared with ordinary diabetic patients.
机译：目的：阐明与线粒体DNA突变有关的糖尿病患者的心脏自主神经功能障碍的程度和特征，其碱基对为3243。研究设计和方法：我们使用24小时动态心电图监测调查了10名糖尿病患者的心率变异性与55位普通糖尿病患者和45位非糖尿病对照受试者进行比较。结果：三组的年龄和性别相似。在具有突变的患者和普通糖尿病患者之间，糖尿病病程和血糖水平没有差异。在心率变异性的时域分析中，具有突变的患者和普通糖尿病患者的SDNN指数和pNN50显着小于对照组。与普通糖尿病患者相比，具有突变的患者的SDNN指数较小（P <0.02），但rMSSD和pNN50并无差异。在频域分析中，具有突变的患者和普通糖尿病患者的总频谱，低频（LF）和高频（HF）谱显着小于对照组。与普通糖尿病患者相比，具有突变的患者的总频谱和低频频谱较小（P <0.02）。但是，HF光谱没有显着差异。值得注意的是，突变患者的LF / HF谱比低于普通糖尿病患者和对照组（P <0.05），但该比率在普通糖尿病患者和对照组中相似。结论：我们的结果表明，与普通糖尿病患者相比，具有线粒体DNA突变的糖尿病患者心脏自主神经功能严重受损，伴有交感迷走失。

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