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首页> 外文期刊>Diabetes care >Short stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994.
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Short stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994.

机译：身材矮小和中年肥胖，胰岛素抵抗和2型糖尿病的风险：1988-1994年第三次全国健康和营养检查调查（NHANES III）。

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OBJECTIVE: To investigate the association between stature-related measurements (height, leg length, and leg length-to-height ratio) and adiposity, insulin resistance, and glucose intolerance. RESEARCH DESIGN AND METHODS: We conducted a cross-sectional analysis of a nationally representative sample of 7,424 adults aged 40-74 years, from the Third National Health and Nutrition Examination Survey (1988-1994). The main outcome measures were percent body fat, homeostasis model assessment of insulin resistance (HOMA-IR), and glucose intolerance based on the World Health Organization's 1985 criteria for an oral glucose tolerance test. RESULTS: Shorter height and leg length, and lower leg length-to-height ratio, were associated with higher percent body fat, especially in women. Lower leg length-to-height ratio was associated with greater insulin resistance estimated by HOMA-IR. In multinomial regression models adjusting for potential confounders, including percent body fat, the relative prevalence of type 2 diabetes per 1-SD lower values in height, leg length, and leg length-to-height ratio were 1.10 (95% CI 0.94-0.29), 1.17 (0.98-1.39), and 1.19 (1.02-1.39), respectively. CONCLUSIONS: Our study supports the hypothesis that adult markers of prepubertal growth, especially leg length-to-height ratio, are associated with adiposity, insulin resistance, and type 2 diabetes in the general U.S. population.
机译：目的：探讨与身材相关的测量（身高，腿长和腿长与身高之比）与肥胖，胰岛素抵抗和葡萄糖耐量之间的关系。研究设计和方法：我们对第三次全国健康与营养检查调查（1988-1994）的7424名40-74岁成年人的全国代表性样本进行了横断面分析。根据世界卫生组织1985年口服葡萄糖耐量试验的标准，主要的结局指标包括体脂百分比，胰岛素抵抗的稳态模型评估（HOMA-IR）和葡萄糖耐受不良。结果：身高和腿长缩短，腿长与身高之比降低，与体内脂肪百分比增加有关，特别是在女性中。小腿长高比与HOMA-IR估计的更高的胰岛素抵抗有关。在针对潜在混杂因素（包括体脂肪百分比）进行调整的多项式回归模型中，每1-SD身高，腿长和腿长与身高比的较低值，2型糖尿病的相对患病率为1.10（95％CI 0.94-0.29） ），1.17（0.98-1.39）和1.19（1.02-1.39）。结论：我们的研究支持这样的假说，即在整个美国人群中，青春期前生长的成人标志物，尤其是腿长与身高的比率与肥胖，胰岛素抵抗和2型糖尿病有关。

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