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首页> 外文期刊>Diabetes care >Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trial.
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Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trial.

机译：铬治疗对西方人群的2型糖尿病患者无效：一项随机，双盲，安慰剂对照试验。

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OBJECTIVE: Chromium treatment has been reported to improve glycemic control in patients with type 2 diabetes. However, concern exists about the possible toxic effects of chromium picolinate. The aim of this study was to determine the effect of chromium treatment in the form of chromium yeast on glycemic control in a Western population of patients with type 2 diabetes who were being treated with oral hypoglycemic agents. RESEARCH DESIGN AND METHODS: In this 6-month, double-blind study, patients with moderate glycemic control, being treated with oral hypoglycemic agents, were randomly assigned to receive either a placebo or treatment with 400 microg of chromium daily in the form of chromium yeast. The primary efficacy parameter was a change in A1C. Secondary end points were changes in lipid profile, BMI, blood pressure, body fat, and insulin resistance. RESULTS: No differences were found for the change in A1C between the intervention and placebo groups, nor were any differences found between the groups for the secondary end points. CONCLUSIONS: There is no evidence that chromium in the form of chromium yeast is effective in improving glycemic control in Western patients with type 2 diabetes who are taking oral hypoglycemic agents.
机译：目的：据报道铬治疗可改善2型糖尿病患者的血糖控制。然而，人们担心吡啶甲酸铬可能产生的毒性作用。这项研究的目的是确定铬酵母形式的铬治疗对正在接受口服降糖药治疗的西方2型糖尿病患者的血糖控制的影响。研究设计和方法：在这项为期6个月的双盲研究中，接受口服降糖药治疗的中度血糖控制患者被随机分配为接受安慰剂或每天以400克铬的形式服用铬酵母。主要功效参数是A1C的变化。次要终点是脂质分布，BMI，血压，体脂和胰岛素抵抗的变化。结果：干预组和安慰剂组之间的A1C变化没有发现差异，次要终点组之间也没有发现任何差异。结论：没有证据表明铬酵母形式的铬可有效改善服用口服降糖药的西方2型糖尿病患者的血糖控制。

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