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首页> 外文期刊>Diabetes research and clinical practice >Coronary disease risk and fasting glucose levels in a non-diabetic population.
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Coronary disease risk and fasting glucose levels in a non-diabetic population.

机译：非糖尿病人群的冠心病风险和空腹血糖水平。

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摘要

We addressed whether or not the risk of coronary heart disease (CHD) in non-diabetic persons is linear at the lower end of fasting glucose levels. Middle-aged Turkish adults (n=2893) free from diabetes and CHD at baseline were studied prospectively over a 7.6-year follow-up. Participants with fasting glucose measurements were analyzed in 3 groups separated by 90 mg/dl and 110 mg/dl limits. Outcomes were analyzed by Cox regression. Cox regression for CHD incidence (n=374) showed an increased age-adjusted risk in the <90 mg/dl fasting glucose group (n=788) [HR 1.32 (1.03; 1.68)], compared with the 90-110 mg/dl group after adjustment for sex, age and the glucose groups. Further adjustment for waist circumference, C-reactive protein and conventional risk factors attenuated the HR to 1.27 (p=0.077). The risk profile in the low-glucose group could not be accounted for by age, smoking status, systolic blood pressure or fasting insulin levels but tended to show higher levels of circulating C-reactive protein. The increased CHD risk observed in individuals with lower compared with higher normal glucose concentrations is likely to be related to an associated pro-inflammatory state.
机译：我们研究了在空腹血糖水平较低时，非糖尿病患者的冠心病（CHD）风险是否呈线性。在7.6年的随访中，对基线时没有糖尿病和冠心病的土耳其中年成年人（n = 2893）进行了前瞻性研究。空腹血糖测量的参与者分为3组，分别以90 mg / dl和110 mg / dl为限。结果通过Cox回归分析。空腹血糖<90 mg / dl组（n = 788）的CHD发生率Cox回归（n = 374）显示经年龄调整的风险增加（HR 1.32（1.03; 1.68）]，而90-110 mg / dl调整性别，年龄和葡萄糖组后的dl组。进一步调整腰围，C反应蛋白和常规危险因素可使HR降至1.27（p = 0.077）。低血糖组的风险状况不能通过年龄，吸烟状况，收缩压或空腹胰岛素水平来解释，但往往显示循环C反应蛋白水平较高。与较高的正常葡萄糖浓度相比，在较低的个体中观察到的CHD风险增加可能与相关的促炎状态有关。

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