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首页> 外文期刊>Diagnostic cytopathology >Cytologic features of ovarian granulosa cell tumors in pleural and ascitic fluids
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Cytologic features of ovarian granulosa cell tumors in pleural and ascitic fluids

机译：胸腹水中卵巢颗粒细胞瘤的细胞学特征

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摘要

Adult granulosa cell tumor (AGCT) is an uncommon neoplasm of the ovary with potential for aggressive behavior and late recurrence. The most important prognostic factor for AGCT is tumor stage. Thus, cytological assessment of pleural or ascitic fluids is crucial for initial staging and subsequent patient management. We report herein two cases of ovarian AGCT presenting with exfoliated tumor cells in pleural and ascitic fluid. The first case involved a 61-year-old woman who presented with stage Ic (a) AGCT. Seven years after initial diagnosis, pleural effusion and pleural dissemination were identified. The second case involved a 50-year-old woman who presented with stage IV AGCT with massive ascites and right pleural effusion. Fluid cytology from both cases showed cohesive or loose clusters of small uniform neoplastic cells with round-to-oval nuclei, coffee-bean-shaped nuclear grooves, small nucleoli, and scant cytoplasm. Call-Exner bodies were also observed in these cytologic specimens. In the differential diagnosis of small monomorphic tumor cells in pleural effusion or ascites, coffee-bean-shaped nuclear grooves and cell clusters forming Call-Exner bodies are diagnostic clues of AGCT. Diagn. Cytopathol. 2015;43:581-584. (c) 2015 Wiley Periodicals, Inc.
机译：成人颗粒细胞瘤（AGCT）是卵巢的罕见肿瘤，具有侵袭性行为和晚期复发的潜力。 AGCT最重要的预后因素是肿瘤分期。因此，对胸膜或腹水的细胞学评估对于初始分期和随后的患者管理至关重要。我们在这里报告了两例卵巢AGCT表现为胸膜和腹水中脱落的肿瘤细胞。第一例涉及一名患有Ic（a）AGCT期的61岁妇女。初步诊断七年后，确定了胸腔积液和胸膜扩散。第二例涉及一名50岁女性，该患者呈IV期AGCT并伴有大量腹水和右胸腔积液。两种情况下的流式细胞学检查均显示凝聚性或疏松性的小均匀肿瘤细胞簇，具有圆形至卵形核，咖啡豆形核槽，小核仁和缺乏的细胞质。在这些细胞学标本中还观察到Call-Exner体。在胸腔积液或腹水中小的单形肿瘤细胞的鉴别诊断中，形成Call-Exner体的咖啡豆形核槽和细胞团是AGCT的诊断线索。诊断细胞病。 2015; 43：581-584。 （c）2015年威利期刊有限公司

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