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Doing more with less: New markers for sarcoma diagnosis and their applicability to cytology specimens

机译：事半功倍：肉瘤诊断的新标志物及其在细胞学标本中的适用性

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摘要

Sarcomas are a rare and extremely diverse set of neoplasms that are often a challenge to diagnose for pathologists. For a number of reasons, primary diagnosis of soft tissue neoplasms is increasingly being performed on small biopsy specimens including fine needle aspiration (FNA) and core needle biopsy (CNB). In the last several years, there has been a significant increase in our understanding of the molecular pathogenesis of this group of tumors. New insights into the genetic mechanisms of tumor formation have been exploited to create a new generation of diagnostic markers that are accessible to most laboratories. This review describes a number of new ancillary markers, and how they can facilitate accurate diagnosis of soft tissue neoplasms on FNA/CNB. Diagn. Cytopathol. 2016;44:351-360. (c) 2016 Wiley Periodicals, Inc.
机译：肉瘤是一套罕见且极为多样化的肿瘤，对于病理学家而言通常是一个挑战。由于多种原因，软组织肿瘤的初步诊断越来越多地用于小型活检标本，包括细针穿刺（FNA）和芯针活检（CNB）。在过去的几年中，我们对这组肿瘤的分子发病机理的认识有了显着提高。已经利用对肿瘤形成的遗传机制的新见解来创建新一代的诊断标记，大多数实验室都可以使用。这篇综述描述了许多新的辅助标记，以及它们如何促进FNA / CNB上软组织肿瘤的准确诊断。诊断细胞病。 2016; 44：351-360。 （c）2016年威利期刊有限公司

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