Azithromycin treatment failure in community-acquired pneumonia caused by Streptococcus pneumoniae resistant to macrolides by a 23S rRNA mutation.

Kays MB; Wack MF; Smith DW; Denys GA

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Azithromycin treatment failure in community-acquired pneumonia caused by Streptococcus pneumoniae resistant to macrolides by a 23S rRNA mutation.

机译：阿奇霉素在社区获得性肺炎中的治疗失败是由23S rRNA突变对大环内酯类耐药的肺炎链球菌引起的。

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In this report, we describe an azithromycin treatment failure in community-acquired pneumonia. During the first three days of azithromycin, the patient's symptoms worsened, and she was subsequently admitted to the hospital. Blood cultures were positive for a penicillin-susceptible, macrolide-resistant S. pneumoniae. DNA sequencing revealed an A2059G mutation in domain V of the 23S rRNA. To our knowledge, this is the first clinical report of an azithromycin failure in the treatment of S. pneumoniae resistant to macrolides by this mechanism.

机译：在本报告中，我们描述了社区获得性肺炎中阿奇霉素治疗失败的情况。在阿奇霉素的前三天，患者的症状恶化，随后被送往医院。血液培养对青霉素敏感的，对大环内酯类耐药的肺炎链球菌呈阳性。 DNA测序显示23S rRNA的结构域V中存在A2059G突变。据我们所知，这是阿奇霉素通过这种机制治疗对大环内酯类耐药的肺炎链球菌失败的首例临床报道。

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《Diagnostic microbiology and infectious disease》 |2002年第2期|共3页
作者
Kays MB; Wack MF; Smith DW; Denys GA;
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正文语种 eng
中图分类传染病;诊断学;
关键词
Azithromycin; Streptococcus pneumoniae; Treatment Failure; RNA; Ribosomal; 叠氮红霉素; 链球菌; 肺炎; 治疗失败; RNA; 核糖体; 肺炎;

机译：Azithromycin;Streptococcus pneumoniae;Treatment Failure;RNA;Ribosomal;叠氮红霉素;链球菌;肺炎;治疗失败;RNA;核糖体;肺炎;

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1. Azithromycin treatment failure in community-acquired pneumonia caused by Streptococcus pneumoniae resistant to macrolides by a 23S rRNA mutation. [J] . Kays MB, Wack MF, Smith DW, Diagnostic microbiology and infectious disease . 2002,第2期

机译：阿奇霉素在社区获得性肺炎中的治疗失败是由23S rRNA突变对大环内酯类耐药的肺炎链球菌引起的。
2. Efficacy of azithromycin as the empiric therapy in children with community-acquired pneumonia who were isolated macrolide resistant Streptococcus pneumoniae from nasopharynx [J] . Nariai A, Okitsu N, Inoue M 感染症学雑誌 . 2004,第6期

机译：阿奇霉素作为从鼻咽分离大环内酯类耐药性肺炎链球菌的社区获得性肺炎患儿的经验性治疗方法
3. Efficacy of azithromycin as the empiric therapy in children with community-acquired pneumonia who were isolated macrolide resistant Streptococcus pneumoniae from nasopharynx [J] . Nariai A, Okitsu N, Inoue M 感染症学雑誌 . 2004,第6期

机译：阿奇霉素作为鼻咽癌分离的肺炎肺炎的儿童审计的疗效疗效
4. COMPARISON OF CAPSULAR POLYSACCHARIDE CONFORMATIONS IN STREPTOCOCCUS AGALACTIAE SEROTYPE III AND STREPTOCOCCUS PNEUMONIAE SEROTYPE 14: IMPLICATIONS FOR IMMUNOGENICS. [C] . Michelle M. Kuttel, Neil Ravenscroft International Carbohydrate Symposium . 2018

机译：链球菌血清型III和链球菌血管型血管型血管型血管型血管型血管型14的比较14：免疫学的影响。
5. Evolution and Molecular Characterization of Clinical Respiratory Macrolide-Resistant Streptococcus pneumoniae in Canada. [D] . Wierzbowski, Aleksandra K. 2012

机译：在加拿大临床抵抗大环内酯类肺炎链球菌的演变和分子特征。
6. Time-Kill Study of the Activity of Telithromycin against Macrolide-Resistant Streptococcus pneumoniae Isolates with 23S rRNA Mutations and Changes in Ribosomal Proteins L4 and L22 [O] . Ralf René Reinert, Adnan Al-Lahham 2005

机译：泰利霉素对大环内酯类耐药肺炎链球菌分离株的23S rRNA突变及核糖体蛋白L4和L22的变化的杀伤力研究。
7. Efficacy of Azithromycin in the Treatment of Community-acquired Pneumonia, Including Patients with Macrolide-Resistant Streptococcus pneumoniae Infection [O] . Yanagihara Katsunori, Izumikawa Koichi, Higa Futoshi, 2009

机译：阿奇霉素治疗社区获得性肺炎的疗效，包括耐大环内酯类肺炎链球菌感染的患者

Azithromycin treatment failure in community-acquired pneumonia caused by Streptococcus pneumoniae resistant to macrolides by a 23S rRNA mutation.

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