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首页> 外文期刊>Developmental biology >DEVELOPMENTAL UTILIZATION OF SPP3A1 AND SPP3A2 - TWO PROTEINS WHICH RECOGNIZE THE SAME DNA TARGET SITE IN SEVERAL SEA URCHIN GENE REGULATORY REGIONS
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DEVELOPMENTAL UTILIZATION OF SPP3A1 AND SPP3A2 - TWO PROTEINS WHICH RECOGNIZE THE SAME DNA TARGET SITE IN SEVERAL SEA URCHIN GENE REGULATORY REGIONS

机译：SPP3A1和SPP3A2的开发利用-在几种海尿蛋白基因调控区识别同一DNA靶位的两种蛋白质。

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摘要

SpP3A1 and SpP3A2 are DNA-binding proteins that interact specifically with the same target sites in the regulatory domains of the Strongylocentrotus purpuratus CyIIIa gene and also of several other known genes. In this work we used antibodies raised against recombinant P3A1 and P3A2 to quantitate these transcription factors in eggs and in the nuclear compartments of embryos of various stages. Both proteins are present in unfertilized eggs, and both enter the embryonic nuclei early in development, but only P3A2 remains present in nuclei at functional concentrations beyond the early gastrula stage. Combined with earlier measurements of P3A site binding at cleavage stages, these measurements show that P3A1 would be replaced by P3A2 at target sites in genes regulated by these factors. (C) 1995 Aeademic Press, Inc. [References: 19]
机译：SpP3A1和SpP3A2是DNA结合蛋白，可与紫罗兰支原体Cypuraus CyIIIa基因以及一些其他已知基因的调节域中的相同靶位点特异性相互作用。在这项工作中，我们使用了针对重组P3A1和P3A2的抗体来定量卵中以及各个阶段胚胎的核室中的这些转录因子。两种蛋白质都存在于未受精的卵中，并且都在发育的早期进入胚核，但是只有P3A2仍以超过早期胃胚期的功能浓度存在于核中。结合在切割阶段对P3A位点结合的早期测量，这些测量表明，在这些因素调控的基因的靶位点，P3A1将被P3A2取代。 （C）1995 Aeademic Press，Inc. [参考：19]

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