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首页> 外文期刊>Developmental cell >Parasympathetic Innervation Regulates Tubulogenesis in the Developing Salivary Gland
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Parasympathetic Innervation Regulates Tubulogenesis in the Developing Salivary Gland

机译：副交感神经调节发育中唾液腺的肾小管生成。

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A fundamental question in development is how cells assemble to form a tubular network during organ formation. In glandular organs, tubulogenesis is a multistep process requiring coordinated proliferation, polarization and reorganization of epithelial cells to form a lumen, and lumen expansion. Although it is clear that epithelial cells possess an intrinsic ability to organize into polarized structures, the mechanisms coordinating morphogenetic processes during tubulogenesis are poorly understood. Here, we demonstrate that parasympathetic nerves regulate tubulogenesis in the developing salivary gland. We show that vasoactive intestinal peptide (VIP) secreted by the innervating ganglia promotes ductal growth, leads to the formation of a contiguous lumen, and facilitates lumen expansion through a cyclic AMP/protein kinase A (cAMP/PKA)-dependent pathway. Furthermore, we provide evidence that lumen expansion is independent of apoptosis and involves the cystic fibrosis transnnembrane conductance regulator (CFTR), a cAMP-regulated Cl(-) channel. Thus, parasympathetic innervation coordinates multiple steps in tubulogenesis during organogenesis.
机译：发展中的一个基本问题是细胞在器官形成过程中如何组装形成管状网络。在腺脏器官中，肾小管生成是一个多步骤过程，需要上皮细胞的协调增殖，极化和重组以形成内腔，以及内腔扩张。尽管很明显上皮细胞具有组织成极化结构的内在能力，但在肾小管发生过程中协调形态发生过程的机制却知之甚少。在这里，我们证明副交感神经调节唾液腺发育中的肾小管生成。我们表明，由神经支配神经节分泌的血管活性肠肽（VIP）促进导管生长，导致形成连续的管腔，并促进通过循环AMP /蛋白激酶A（cAMP / PKA）依赖性途径的管腔扩张。此外，我们提供的证据表明，管腔扩张与细胞凋亡无关，并且涉及囊性纤维化跨膜电导调节剂（CFTR），cAMP调节的Cl（-）通道。因此，副交感神经支配协调器官发生期间肾小管发生的多个步骤。

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