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首页> 外文期刊>Digestive Diseases and Sciences >Long-term outcomes of prophylactic endoscopic histoacryl injection for gastric varices with a high risk of bleeding.
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Long-term outcomes of prophylactic endoscopic histoacryl injection for gastric varices with a high risk of bleeding.

机译：胃内静脉曲张的预防性内窥镜组织丙烯酸注射液的长期预后具有很高的出血风险。

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PURPOSE: Endoscopic histoacryl injection (EHI) is reported to be an effective treatment modality for bleeding gastric varices (GVs) but controversial as a prophylactic treatment for non-bleeding GVs because efficacy and safety have yet to be determined. The aim of this study was to evaluate safety and long-term outcomes of prophylactic EHI for non-bleeding GVs with a high risk of bleeding. METHODS: Thirty-three patients (23 males/10 females, mean age 56.6 years old) with a high risk of gastric variceal bleeding (large tumorous (27), red color sign (14) or rapidly growing in size (1)) underwent EHI. According to the grade of GVs, 25 patients belonged to F3, seven to F2, and one to F1. In terms of the locations of GVs, four patients belonged to type IGV1, 21 to type GOV2, and eight to type GOV1. RESULTS: Obliteration of GVs was achieved in all of the treated patients. Twenty-three patients required one session and ten needed more than two sessions to obliterate their GVs. A mean volume of histoacryl used per session was 2.0 ml. Complications related to the procedure included immediate bleeding in two patients and bacteremia in one patient. The mean duration of follow-up was 12.2 months and eradication of GVs was achieved in 21 (95%) of 22 patients who were followed-up more than 3 months. Index GVs recurred in three of 21 patients (14%) and re-bleeding in index GVs after EHI occurred in two of 26 patients (8%). CONCLUSIONS: Prophylactic EHI can be a promising procedure for eradication of non-bleeding GVs in case with a high risk of bleeding.
机译：目的：内镜下组织丙烯酸注射液（EHI）被报道是治疗胃底静脉曲张（GVs）的有效方法，但由于尚未确定其疗效和安全性，因此作为预防出血性GVs的方法引起争议。这项研究的目的是评估具有出血风险的非出血型GV的预防性EHI的安全性和长期结果。方法：对33例胃静脉曲张破裂出血高风险（大肿瘤（27），红色体征（14）或大小迅速增长（1））的患者（男23例，女10例，平均年龄56.6岁）进行了研究。 EHI。根据GV的等级，F3有25例，F2有7例，F1有1例。就GV的位置而言，四名患者属于IGV1型，21名属于GOV2型，八名属于GOV1型。结果：在所有接受治疗的患者中，GVs均消失。 23名患者需要进行一次疗程，而十名则需要进行两次以上的疗程才能消除GV。每次使用的组织丙烯酸平均体积为2.0 ml。与手术相关的并发症包括两名患者的立即出血和一名患者的菌血症。平均随访时间为12.2个月，在随访3个月以上的22例患者中，有21例（95％）根除了GV。在21例患者中有3例（14％）复发了GV指数，在26例患者中有2例（8％）发生了EHI后，GV指数再次出血。结论：在出血风险较高的情况下，预防性EHI可能是根除非出血性GV的有前途的方法。

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