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首页> 外文期刊>Digestive Diseases and Sciences >Nizatidine and gastric emptying in functional dyspepsia.
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Nizatidine and gastric emptying in functional dyspepsia.

机译：尼扎替丁和胃排空的功能性消化不良。

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In clinical practice, H2-receptor antagonists, including nizatidine, in addition to their use in the treatment of peptic ulcer and gastroesophageal reflux, are also useful in alleviating dyspeptic symptoms. Patients with functional dyspepsia show a tendency to delayed gastric emptying. Results of preliminary studies have demonstrated that nizatidine has a prokinetic effect due to its cholinergic properties. The aim of this study was to evaluate the effect of nizatidine on gastric emptying in patients with functional dyspepsia. Sixteen patients with dyspeptic symptoms referred for gastroscopy by primary care physicians were enrolled in this randomized, placebo-controlled, double-blind cross-over study. They received nizatidine 150 mg twice daily or placebo for 2 months. After a 1-month washout period, the 2-month treatment was repeated, with these patients acting as their own controls. Gastric emptying was measured by scintigraphy, and dyspeptic symptoms and quality of life were evaluated at the end of both treatment periods. Gastric emptying of solids during nizatidine therapy was prolonged (T1/2 110.1 +/- 76.7 vs. 65.6 +/- 23.2 min, P = 0.03), but nizatidine had no effect on gastric emptying of liquids. Nizatidine improved the symptom scores and seven of eight aspects of quality of life - but not significantly. In conclusion, nizatidine decreases the gastric emptying rate of solids without having a significant effect on symptoms or quality of life in functional dyspepsia.
机译：在临床实践中，H2-受体拮抗剂，包括尼扎替丁，除了用于治疗消化性溃疡和胃食管反流外，还可用于缓解消化不良症状。功能性消化不良患者表现出胃排空延迟的趋势。初步研究结果表明，尼扎替丁由于其胆碱能特性而具有促动力作用。这项研究的目的是评估尼扎替丁对功能性消化不良患者胃排空的影响。这项随机，安慰剂对照，双盲交叉研究纳入了16位由初级保健医师转诊为胃镜检查的消化不良症状的患者。他们每天两次接受尼扎替丁150 mg或安慰剂治疗2个月。经过1个月的冲洗期后，重复2个月的治疗，将这些患者作为自己的对照。通过闪烁显像法测量胃排空，并在两个治疗期结束时评估消化不良症状和生活质量。尼扎替丁治疗期间胃排空固体的时间延长（T1 / 2 110.1 +/- 76.7与65.6 +/- 23.2分钟，P = 0.03），但尼扎替丁对胃液的排空没有影响。尼扎替丁可改善症状评分和生活质量八个方面中的七个，但不明显。总之，尼扎替丁降低了固体的胃排空率，而对功能性消化不良的症状或生活质量没有显着影响。

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