Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-dysiherbaine.

Cohen JL; Limon A; Miledi R; Chamberlin AR

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Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-dysiherbaine.

机译：基于（-）-dysiherbaine结构的iGluR配体支架的设计，合成和生物学评估。

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摘要

The design and synthesis of four 2,2-disubstituted dihydrobenzofurans that are structurally related to several glutamate-containing natural products, including (-)-dysiherbaine, is described. Biological evaluation of these analogs shows that one is a KA receptor antagonist and another is an NMDA receptor agonist.

机译：描述和结构上与几种含谷氨酸的天然产物（包括（-）-dysiherbaine）相关的四个2,2-二取代的二氢苯并呋喃的设计和合成。这些类似物的生物学评估表明，一种是KA受体拮抗剂，另一种是NMDA受体激动剂。

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《Bioorganic and Medicinal Chemistry Letters》 |2006年第8期|共6页
作者
Cohen JL; Limon A; Miledi R; Chamberlin AR;
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正文语种 eng
中图分类药学;生物化学;
关键词
Alanine; Benzofurans; Bicyclo Compounds; Heterocyclic; Excitatory Amino Acid Antagonists; 丙氨酸; 苯呋喃类; 二环化合物; 杂环; 兴奋性氨基酸拮抗剂; 受体; 谷氨酸; 受体; N-甲基-D-天冬氨酸;

机译：Alanine;Benzofurans;Bicyclo Compounds;Heterocyclic;Excitatory Amino Acid Antagonists;丙氨酸;苯呋喃类;二环化合物;杂环;兴奋性氨基酸拮抗剂;受体;谷氨酸;受体;N-甲基-D-天冬氨酸;

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1. Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-dysiherbaine. [J] . Cohen JL, Limon A, Miledi R, Bioorganic and Medicinal Chemistry Letters . 2006,第8期

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Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-dysiherbaine.

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