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首页> 外文期刊>Drug development and industrial pharmacy >Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine.
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Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine.

机译：硝苯地平新型喷雾包衣的软弹性明胶胶囊缓释制剂的研制。

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摘要

Nifedipine release from coated commercially available immediate release soft elastic gelatin capsules was investigated. Capsules were spray coated using two different polymeric combinations, ethylcellulose and hydroxypropylmethylcellulose or pectin, at different coating loads. In vitro drug release studies were conducted in three different dissolution media: with gastric pretreatment, without gastric pretreatment, and in water to investigate the pH effect on nifedipine release. Convolution of in vitro dissolution data for selected formulations and commercially available sustained release nifedipine formulations showed that the tested formulations provided release profiles of nifedipine that are very promising in terms of desirable sustained release formulations.
机译：研究了硝苯地平从包衣的市售速释软弹性明胶胶囊中的释放。使用两种不同的聚合物组合（乙基纤维素和羟丙基甲基纤维素或果胶）以不同的涂覆量对胶囊进行喷涂。在三种不同的溶出介质中进行了体外药物释放研究：使用胃预处理，不使用胃预处理以及在水中研究pH值对硝苯地平释放的影响。选定制剂和市售缓释硝苯地平制剂的体外溶出数据的卷积表明，所测试的制剂提供了硝苯地平的释放曲线，就所需的缓释制剂而言，这非常有希望。

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