Drug-induced arrhythmias and sudden cardiac death: implications for the pharmaceutical industry

KilleenM.J.

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Drug-induced arrhythmias and sudden cardiac death: implications for the pharmaceutical industry

机译：药物性心律失常和心源性猝死：对制药行业的影响

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Following a series of high profile withdrawals from the market, the ability of medications to induce potentially fatal arrhythmias is a significant problem facing the pharmaceutical industry. Current preclinical cardiac safety assays are based on the assumption that blockade of a single repolarizing K+ channel alone precipitates drug-induced arrhythmias, however, current findings point to a range of more complex arrhythmogenic mechanisms. This review begins by exploring clinical findings and potential mechanisms underlying drug-induced sudden cardiac death and then goes on to assess current and explore future strategies to detect cardiotoxicity at the preclinical stage.

机译：在一系列高调退出市场后，药物引起潜在致命性心律失常的能力成为制药行业面临的重大问题。当前的临床前心脏安全性测定基于这样一个假设，即仅单个单个极化K +通道的阻滞会引起药物诱发的心律失常，但是，目前的发现指向一系列更复杂的心律失常机制。这篇综述首先探讨了临床发现和药物诱发的心源性猝死的潜在机制，然后继续评估了当前的情况，并探讨了在临床前阶段检测心脏毒性的未来策略。

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《Drug discovery today》 |2009年第12期|共9页
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KilleenM.J.;
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正文语种 eng
中图分类药学;
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1. Drug-induced arrhythmias and sudden cardiac death: implications for the pharmaceutical industry [J] . KilleenM.J. Drug discovery today . 2009,第11a12期

机译：药物性心律失常和心源性猝死：对制药行业的影响
2. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC) Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC) [J] . Priori Silvia G., Blomstrom-Lundqvist Carina, Mazzanti Andrea, European Heart Journal: The Journal of the European Society of Cardiology . 2015,第41期

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3. Microvolt T-wave alternans and electrophysiologic testing predict distinct arrhythmia substrates: implications for identifying patients at risk for sudden cardiac death. [J] . Amit G, Rosenbaum DS, Super DM, Heart rhythm: the official journal of the Heart Rhythm Society . 2010,第6期

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4. Intra-beat Scaling Properties of Cardiac Arrhythmias and Sudden Cardiac Death [C] . Eduardo Rodriguez, Claudia Lerma, Juan C. Echeverria, Mexican Meeting on Mathematical and Experimental Physics . 2008

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5. Functional characterization of SCN5A, the cardiac sodium channel gene associated with cardiac arrhythmias and sudden death [D] . Wu, Ling 2008

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7. ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) [O] . Zipes Douglas P., Camm A. John, Borggrefe Martin, 2006

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Drug-induced arrhythmias and sudden cardiac death: implications for the pharmaceutical industry

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