Toxicoproteomics -- a new preclinical tool.

Bandara LR; Kennedy S

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Toxicoproteomics -- a new preclinical tool.

机译：毒理蛋白质组学-一种新的临床前工具。

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The publication of the human genome has presented the scientific community with an unprecedented amount of genetic information with the potential to revolutionize the drug discovery process. This information could be used to identify novel drug targets and disease markers or could aid in the development of personalized medicines. The realization that genetic changes must ultimately influence protein function has pushed the field of proteomics further into the limelight. In this review the applications of proteomics to the field of toxicology will be discussed. It is anticipated that, in the future, toxicologists will apply a range of genomic and proteomic techniques to address issues in toxicity.

机译：人类基因组的出版为科学界提供了前所未有的遗传信息，并有可能改变药物发现过程。该信息可用于识别新型药物靶标和疾病标志物，或有助于个性化药物的开发。基因改变必须最终影响蛋白质功能的认识已将蛋白质组学领域进一步引人注目。在这篇综述中，将讨论蛋白质组学在毒理学领域的应用。预计将来，毒理学家将应用一系列基因组学和蛋白质组学技术来解决毒性问题。

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《Drug discovery today》 |2002年第7期|共8页
作者
Bandara LR; Kennedy S;
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正文语种 eng
中图分类药学;
关键词
Drug Evaluation; Preclinical; Proteomics; Toxicology; 毒理学;

机译：Drug Evaluation;Preclinical;Proteomics;Toxicology;毒理学;

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专利

1. Toxicoproteomics -- a new preclinical tool. [J] . Bandara LR, Kennedy S Drug discovery today . 2002,第7期

机译：毒理蛋白质组学-一种新的临床前工具。
2. Cytotoxicity and toxicoproteomic analyses of human lung epithelial cells exposed to extracts of atmospheric particulate matters on PTFE filters using acetone and water [J] . Ecotoxicology and Environmental Safety . 2020,第Mara期

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3. Using a toxicoproteomic approach to investigate the effects of thiamethoxam into the brain of Apis mellifera [J] . Roat Thaisa C., Aparecido dos Santos-Pinto Jose Roberto, Miotelo Lucas, Chemosphere . 2020,第Nova期

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4. Investigation of the in-vitro Toxicoproteomic Response of Pulmonary Epithelial Cells to Well-Characterized Atomic Layer Deposition-Coated Carbon Nanotube Exposure [C] . Gina Hilton, Alexia Taylor, James Bonner, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：肺上皮细胞对特征原子层沉积碳纳米管暴露的体外毒催乳剂的研究
5. Preclinical Development of Single Walled Carbon Nanotube-Based Optical Biosensors [D] . Hofferber, Eric M. 2021

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6. Toxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid [O] . Christopher Trent Brewer, Kiran Kodali, Jing Wu, 2020

机译：用利福平和异烟肼处理的HPXR转基因小鼠的毒蛋白曲线分析
7. Finish Rolling of Sintered Fe Alloy Gears Using Screw-Shaped Tool. 1st Report, Rolling Experiments by Standard Screw-Shaped Tool. [O] . Teruie TAKEMASU, Tatsuo OZAKI, Hiroshi MIYAHARA, 2002

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8. Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma as a Preclinical Tool. [R] . Becher, O. 2014

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Toxicoproteomics -- a new preclinical tool.

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