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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >An integrated approach to the study of Chlamydia trachomatis infection of the female genital tract.
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An integrated approach to the study of Chlamydia trachomatis infection of the female genital tract.

机译：研究沙眼衣原体感染女性生殖道的综合方法。

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摘要

The two major aims of this thesis were firstly, to provide a basis for an integrated approach to study the oculogenital biovar of Chlamydia trachomatis in order to explain the complex and varied course of female genital tract infection; and secondly, to use the understanding gained through this approach to suggest possible intervention strategies. To accomplish this end, the projects conducted and reported upon in the thesis fall into four categorical sections. Part I of the thesis addresses the bacterial factors that contribute to the pathogenesis of infection using both in vitro observations and an in vivo experimental murine model. In Part II, host immunogenetic factors are analyzed using gene knockout mice and single nucleotide polymorphism (SNP) analysis of human genes. In Part III, the efficacy of prophylactic intervention on the susceptibility and course of female genital tract infection with C. trachomatis in the mouse is evaluated. Finally, in Part IV, the natural immune response to the pathogen and the relationship that these responses have on conferring protection and/or contributing to the pathology of disease are investigated to bring us closer to the ultimate protective intervention strategy: a vaccine against C. trachomatis. This article summarizes the aims and results of the thesis, followed by a general discussion and conclusions.
机译：本论文的两个主要目的是：首先，为研究沙眼衣原体的眼生殖器生物变体的综合方法提供基础，以解释女性生殖道感染的复杂性和多样性。其次，利用通过这种方法获得的理解来建议可能的干预策略。为了达到这个目的，论文中进行和报告的项目分为四个类别。本文的第一部分使用体外观察和体内实验鼠模型研究了导致感染发病机理的细菌因素。在第二部分中，使用基因敲除小鼠和人类基因的单核苷酸多态性（SNP）分析来分析宿主免疫遗传因子。在第三部分中，评估了预防性干预对小鼠沙眼衣原体女性生殖道感染的敏感性和病程的功效。最后，在第四部分中，研究了对病原体的天然免疫应答以及这些应答与提供保护和/或促进疾病病理的关系，以使我们更接近最终的保护性干预策略：针对C的疫苗。沙眼本文总结了论文的目的和结果，然后进行了一般性的讨论和结论。

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