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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >Sodium oxybate: efficacy, safety and tolerability in the treatment of narcolepsy with or without cataplexy.
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Sodium oxybate: efficacy, safety and tolerability in the treatment of narcolepsy with or without cataplexy.

机译：羟丁酸钠：治疗发作性睡病伴或不伴猝倒症的疗效，安全性和耐受性。

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摘要

Sodium oxybate is the sodium salt of gamma- hydroxybutyrate, an endogenous cerebral inhibitory neurotransmitter. It is licensed in the United States for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy and in the European Union for the treatment of narcolepsy with cataplexy. Its mode of action is uncertain, but it increases 5-hydroxytryptamine turnover, interacts with opioid systems and may act as a gamma-aminobutyric acid B receptor agonist (GABA(B)). It is rapidly absorbed and eliminated, having a mean elimination half-life of 30-60 minutes. In controlled trials in narcolepsy without cataplexy, it decreased excessive daytime sleepiness and increased several quality of life domains. In combination with modafinil, it exerted an additive effect in diminishing daytime sleepiness. Both acute (four to eight weeks) and chronic (12 months) studies have demonstrated sodium oxybate's efficacy in decreasing cataplectic attack frequency. It is well tolerated with adverse event withdrawal rates of approximately 3-10% after acute and chronic administration. There is no clear evidence of a withdrawal syndrome after abrupt cessation of therapeutic doses. Sodium oxybate appears to be an effective and well-tolerated treatment for all the key symptoms of the two forms of narcolepsy.
机译：羟丁酸钠是内源性大脑抑制性神经递质γ-羟基丁酸钠的钠盐。它在美国获得许可，用于治疗发作性睡病患者的过度白天嗜睡和瘫痪症，并获得欧洲联盟的许可，用于治疗发作性睡病的发作性睡病。它的作用方式尚不确定，但会增加5-羟色胺的转换，与阿片样物质系统相互作用，并可能充当γ-氨基丁酸B受体激动剂（GABA（B））。它被迅速吸收和消除，消除半衰期平均为30-60分钟。在没有发作性发作的发作性睡病的对照试验中，它减少了白天过多的嗜睡，并增加了一些生活质量。与莫达非尼合用时，它在减少日间嗜睡方面具有加和作用。急性（四到八周）和慢性（十二个月）研究都证明了羟丁酸钠在降低重症发作频率方面的功效。急性和慢性给药后，不良反应发生率约为3-10％，耐受性良好。没有明确证据表明突然停止治疗剂量后会出现戒断综合征。对于两种形式的发作性睡病的所有关键症状，羟丁酸钠似乎是一种有效且耐受良好的治疗方法。

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