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首页> 外文期刊>Drug and alcohol review >Problem drinking in relation to treatment outcome among opiate addicts in methadone maintenance treatment.
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Problem drinking in relation to treatment outcome among opiate addicts in methadone maintenance treatment.

机译：美沙酮维持治疗中阿片成瘾者与治疗结果相关的饮酒问题。

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This study analyzed indicators of alcohol-related problems in opiate addicts before, during, and after leaving methadone maintenance treatment (MMT), in relation to illicit drug use and retention in treatment. The study was based on 204 patients, admitted to MMT for the first time between 1 January 1995 and 31 July 2000, and followed until 31 December 2000. Three measures were used to indicate alcohol use and alcohol-related problems; records of hospital care with an alcohol-related diagnosis, any treatment with alcohol-sensitizing drugs (disulfiram or calcium carbimide) during MMT, and results of the 5-hydroxytryptophol to 5-hydroxyindoleacetic acid ratio (5HTOL/5HIAA) in urine, a sensitive biomarker for recent drinking. Use of illicit drugs was determined by routine urine drug testing. About one third of the patients (n = 69) had a lifetime prevalence of hospital treatment for an alcohol-related diagnosis, 45 of whom had been hospitalized (mean 4.2 stays) prior to the start of MMT. There was a significant association (p<0.05) between the number of alcohol-related diagnoses prior to treatment and a positive 5HTOL/5HIAA test during MMT. The alcohol indicators first became positive on average 1.6 years after admission to treatment, compared with after about 4 months for illicit drugs. Use of cannabis or benzodiazepines was significantly associated with alcohol use. Female methadone patients with indications of alcohol-related problems relapsed more often into illicit drug use than did women without such indications (3.9 vs. 2.5 relapse periods/year; p<0.005), whereas no significant association was found for men. The results of the present study indicate that drinking problems among patients undergoing MMT is associated with an increased risk of relapse into illicit drug use and with discharge from treatment. Concurrent treatment of alcohol-related problems, including systematic monitoring of alcohol use, therefore should be recommended to reduce the risk for relapse into illicit drug use and improve overall treatment outcome in MMT.
机译：这项研究分析了美沙酮维持治疗（MMT）之前，之中和之后与阿片成瘾者的酒精相关问题的指标，这些指标与非法药物的使用和治疗的保留有关。该研究基于204位患者，他们于1995年1月1日至2000年7月31日首次接受MMT治疗，随后一直持续到2000年12月31日。酒精相关诊断的医院护理记录，MMT期间使用酒精敏感性药物（双硫仑或碳化二钙）进行的任何治疗以及尿液中5-羟色氨酸与5-羟吲哚乙酸之比（5HTOL / 5HIAA）的结果，最近饮用的生物标志物。通过常规尿液药物检测确定了非法药物的使用。大约三分之一的患者（n = 69）终生盛行酒精相关诊断的医院治疗，其中45名在MMT开始之前已经住院（平均住院4.2次）。在治疗前与酒精相关的诊断数与MMT期间5HTOL / 5HIAA试验阳性之间存在显着相关性（p <0.05）。酒精指标在入院后平均1.6年首次开始呈阳性，而非法药物约在4个月后才开始呈阳性。大麻或苯二氮卓类药物的使用与酒精的使用显着相关。具有酒精相关问题征兆的女性美沙酮患者比没有此类征兆的女性更容易复发为非法药物使用（3.9 vs. 2.5复发期/年; p <0.005），而男性则没有显着关联。本研究的结果表明，接受MMT治疗的患者中的饮酒问题与非法药物使用复发的风险增加以及治疗出院有关。因此，建议同时治疗酒精相关问题，包括系统地监控酒精使用情况，以减少再次滥用毒品的风险，并改善MMT的总体治疗效果。

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