• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>DTW:Deutsche Tierarztliche Wochenschrift >The effect of kefir on glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) levels in mice with colonic abnormal crypt formation (ACF) induced by azoxy-methane (AOM)
【24h】

The effect of kefir on glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) levels in mice with colonic abnormal crypt formation (ACF) induced by azoxy-methane (AOM)

机译：开菲尔对由乙氧基甲烷（AOM）诱发的具有结肠异常隐窝形成（ACF）的小鼠中的谷胱甘肽（GSH），丙二醛（MDA）和一氧化氮（NO）水平的影响

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study we investigated the effect of kefir on the levels of glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO) in the liver, stomach, spleen and colon of mice with colonic aberrant crypts formed by azoxymethane (AOM). Thirty 12 weeks old Swiss Albino mice averaging 31.5 g weight were used as experimental animals. The mice were separated into 3 groups. The first group was the control group, second group was the AOM and third group was the AOM+kefir group. We applied AOM to the second and third groups. Mice were fed ad libitum by laboratory rodent chow during the experiment period. Water was given to the first and second groups and third group received only kefir diluted with water (50 %). AOM was injected subcutaneously to the secondand third groups for 7 weeks (two times a week, 5 mg/kg). Six weeks after the final AOM treatment the animals were sacrificed and liver, stomach, spleen and colon samples were collected from all the groups. MDA level demonstrated an increase only in stomach for the third group (p < 0.001), while an elevation was observed for all of the four organs for the second group (spleen p < 0.001, liver p < 0.001, colon p < 0.01). GSH level showed an increase in the second group at stomach (p < 0.01) and colon (p< 0.001), while in the third group, a small increase was determined only at the colon (p < 0.05). NO level increased at all of the organs in the second group (spleen, liver, colon p < 0.001, stomach p < 0.05), but only at liver and colon in the third group3 (p < 0.001). In conclusion these results showed that kefir plays an antioxidant role
机译：在这项研究中，我们研究了开菲尔对小鼠的肝脏，胃，脾和结肠中谷胱甘肽（GSH），丙二醛（MDA），一氧化氮（NO）水平的影响，这些小鼠具有由乙氧基甲烷（AOM）形成的结肠异常隐窝。将平均体重为31.5g的30只12周龄的瑞士白化小鼠用作实验动物。将小鼠分为3组。第一组为对照组，第二组为AOM，第三组为AOM +开菲尔组。我们将AOM应用于第二和第三组。在实验期间，通过实验室啮齿动物食物随意喂养小鼠。第一组和第二组都喝水，第三组只用水（50％）稀释开菲尔。将AOM皮下注射到第二和第三组，持续7周（每周两次，每次5 mg / kg）。最终AOM处理后六周，处死动物，并从所有组中收集肝，胃，脾和结肠的样本。 MDA水平显示第三组仅在胃中增加（p <0.001），而第二组所有四个器官均观察到升高（脾p <0.001，肝脏p <0.001，结肠p <0.01）。 GSH水平显示第二组在胃（p <0.01）和结肠（p <0.001）升高，而第三组仅在结肠（p <0.05）升高。第二组中所有器官的NO水平均升高（脾，肝，结肠p <0.001，胃p <0.05），但第三组中只有肝脏和结肠3（p <0.001）。总之，这些结果表明开菲尔起着抗氧化作用

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号