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首页> 外文期刊>Circulation journal >Effect of Losartan and Amlodipine on Left Ventricular Diastolic Function in Patients With Mild-to-Moderate Hypertension (J-ELAN): rationale and design.
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Effect of Losartan and Amlodipine on Left Ventricular Diastolic Function in Patients With Mild-to-Moderate Hypertension (J-ELAN): rationale and design.

机译：氯沙坦和氨氯地平对轻度至中度高血压（J-ELAN）患者左心室舒张功能的影响：原理和设计。

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BACKGROUND: Hypertension is a major underlying disease that may cause left ventricular (LV) diastolic dysfunction, even without LV systolic dysfunction, and antihypertensive drugs could affect LV diastolic function. METHODS AND RESULTS: The Effect of Losartan and Amlodipine on Left Ventricular Diastolic Function in Patients With Mild-to-Moderate Hypertension (J-ELAN) study is a multicenter, prospective, randomized trial designed to assess the effects of losartan and amlodipine on LV diastolic function in hypertensive patients with LV diastolic dysfunction in the absence of systolic dysfunction. A total of 300 patients (150 patients in each group) will be enrolled. In addition to Doppler echocardiographic indices of LV diastolic function, changes in LV structure and atherosclerosis of the carotid arteries will be serially assessed. The maximum follow-up period is 18 months. CONCLUSIONS: This study will provide the characteristic differences in the effects of amlodipine and losartan on LV diastolic dysfunction in hypertensive patients.
机译：背景：高血压是一种主要的潜在疾病，即使没有左心室收缩功能障碍，也可能引起左心室（LV）舒张功能障碍，降压药可能会影响左心室舒张功能。方法和结果：氯沙坦和氨氯地平对轻度至中度高血压患者左室舒张功能的影响是一项多中心，前瞻性，随机试验，旨在评估氯沙坦和氨氯地平对左室舒张期的影响左室舒张功能障碍的高血压患者在没有收缩功能障碍的情况下的功能。总共将招募300位患者（每组150位患者）。除了左心室舒张功能的多普勒超声心动图指标外，还将连续评估左心室结构的左心室结构和动脉粥样硬化的变化。最长随访期为18个月。结论：本研究将提供氨氯地平和氯沙坦对高血压患者左室舒张功能障碍的影响的特征差异。

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