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首页> 外文期刊>Circulation journal >Long-term prognosis of patients with paroxysmal atrial fibrillation depends on their response to antiarrhythmic therapy.
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Long-term prognosis of patients with paroxysmal atrial fibrillation depends on their response to antiarrhythmic therapy.

机译：阵发性房颤患者的长期预后取决于他们对抗心律不齐疗法的反应。

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BACKGROUND: The rhythm control treatment strategy for persistent atrial fibrillation (AF) has been shown not to improve quality of life or prognosis any more than rate control. It is unclear whether the prognosis of the patients with paroxysmal AF (PAF) is influenced by the response to antiarrhythmic drug therapy (AAT). METHODS AND RESULTS: The relationship between the response to AAT and long-term prognosis was evaluated in 290 patients with PAF (mean age, 69 years). During a mean follow-up period of 51 months, 114 patients (39%) had no recurrence of AF (Group 1), 113 (39%) had repeated AF recurrence (Group 2), and the remaining 63 (22%) had permanent AF despite AAT (Group 3). The survival rate without any cardiovascular deaths at 60 months was 99% in Group 1, 95% in Group 2 and 94% in Group 3 (p=NS among 3 groups). Survival rate without symptomatic ischemic stroke was 99% in Group 1, 88% in Group 2 and 76% in Group 3 (p<0.05 Group 1 vs Groups 2 and 3). The annual rate of stroke in the patients with warfarin treatment was similar among the 3 groups, whereas that in the patients without warfarin was higher in Groups 2 and 3 than in Group 1. CONCLUSIONS: Long-term prognosis of patients with PAF varies with the response to AAT: When sinus rhythm is maintained, the prognosis is good even without anticoagulation therapy.
机译：背景：持续性心房颤动（AF）的节律控制治疗策略已显示出比速率控制更能改善生活质量或预后。目前尚不清楚阵发性AF（PAF）患者的预后是否受到抗心律失常药物疗法（AAT）的反应的影响。方法和结果：对290名PAF患者（平均年龄69岁）对AAT的反应与长期预后之间的关系进行了评估。在平均51个月的随访期间，114例（39％）无房颤复发（组1），113例（39％）反复房颤复发（组2），其余63例（22％）房颤复发尽管有AAT，仍为永久性AF（第3组）。第1组在60个月时无心血管死亡的生存率是99％，第2组是95％，第3组是94％（3组中p = NS）。第1组无症状性缺血性卒中的生存率为99％，第2组为88％，第3组为76％（p <0.05，第1组与第2和第3组相比）。 3组中使用华法林治疗的患者的年中风发生率相似，而第2组和第3组中不使用华法林的患者的年中风发生率高于第1组。对AAT的反应：维持窦性心律时，即使没有抗凝治疗也预后良好。

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