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首页> 外文期刊>Circulation journal >Prevention of atherosclerosis in overweight/obese patients. - In need of novel multi-targeted approaches-.
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Prevention of atherosclerosis in overweight/obese patients. - In need of novel multi-targeted approaches-.

机译：预防超重/肥胖患者的动脉粥样硬化。 -需要新颖的多目标方法。

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Obesity has reached epidemic proportions and complications related to obesity contribute substantially to both healthcare costs and mortality. Obesity, particularly when accompanied by an excess of visceral/ectopic fat, is a major risk factor for diseases ranging from insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. The epidemic proportions reached by obesity has made these conditions a global problem in human health. Accordingly, preventive and/or therapeutic interventions should be considered in obese patients. Regular physical activity/exercise has numerous beneficial effects on the cardiometabolic risk profile and on the cardiovascular system. However, our current clinical environment is not designed to provide the regular support needed by patients to help them maintain over the long term their improved physical activityutritional habits. Because hypertension, dyslipidemia, hyperinsulinemia, and excess visceral adipose tissue are linked by complex reciprocal molecular interactions, it is logical to expect that targeting an interconnected pathway may provide multiple benefits. At this stage, combined therapy of statins or PPAR agonists and renin-angiotensin-aldosterone system blockers to target multiple therapeutic pathways may optimally improve the cardiometabolic risk profile through both distinct and interrelated mechanisms. In the present article, we will discuss updated novel approaches, including potential multi-targeted intervention strategies, based on underlying pathophysiological processes.
机译：肥胖症已经达到流行病的程度，并且与肥胖症相关的并发症在很大程度上增加了医疗费用和死亡率。肥胖，尤其是伴随着过多的内脏/异位脂肪，是导致胰岛素抵抗，2型糖尿病，非酒精性脂肪肝和心血管疾病等疾病的主要危险因素。肥胖达到的流行程度使这些疾病成为人类健康中的全球性问题。因此，肥胖患者应考虑预防和/或治疗干预。定期进行体育锻炼对心脏代谢风险和心血管系统具有许多有益的作用。但是，我们当前的临床环境并非旨在为患者提供所需的常规支持，以帮助他们长期维持改善的体育活动/营养习惯。由于高血压，血脂异常，高胰岛素血症和过多的内脏脂肪组织是通过复杂的相互分子相互作用而联系在一起的，因此合乎逻辑的预期是，靶向相互连接的途径可能会带来多种益处。在这一阶段，针对他汀类药物或PPAR激动剂和肾素-血管紧张素-醛固酮系统阻滞剂的联合治疗，以多种治疗途径为目标，可以通过不同的和相互关联的机制来最佳地改善心脏代谢风险。在本文中，我们将基于基础病理生理过程讨论更新的新颖方法，包括潜在的多目标干预策略。

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