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首页> 外文期刊>JAMA otolaryngology-- head & neck surgery >Recurrent contact granuloma: Experience with excision and botulinum toxin injection
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Recurrent contact granuloma: Experience with excision and botulinum toxin injection

机译：复发性接触性肉芽肿：切除和肉毒杆菌毒素注射的经验

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Importance: Contact granuloma is a difficult-to-treat laryngeal disorder associated with vocal abuse, habitual throat clearing, and laryngopharyngeal reflux. It has a high propensity for persistence and recurrence despite many treatment alternatives. Objective: To present our experience with recurrent contact granuloma treated with microlaryngoscopic excision and botulinum toxin injection. Design: Case series. The follow-up period had a mean (range) of 41 (11-88) months. Setting: Tertiary referral university clinic. Participants: Twenty patients with recurrent, grade 3 and grade 4 contact granuloma whose lesion was excised at least once after failure of conservative treatments. Interventions: Microlaryngoscopic excision and- botulinum toxin type A injection into the region of the bilateral thyroarytenoid and lateral cricoarytenoid muscles. Main Outcomes and Measures: Disappearance of contact granuloma. Results: Seventeen patients were cured of their contact granuloma. Three patients experienced recurrences: 2 received botulinum toxin injection only as outpatients and recovered. The other patient required reexcision and reinjection under general anesthesia. These 3 patients were free of granuloma at their last follow-up. Conclusions and Relevance: After failed conservative treatment, microlaryngoscopic excision and botulinum toxin type A injection is successful in the treatment of recurrent contact granuloma. Removing recurrent granulomas can result in a low recurrence rate if botulinum toxin type A is added at the time of removal.
机译：重要性：接触性肉芽肿是一种难以治疗的喉部疾病，与嗓音滥用，习惯性喉咙清理和喉咽反流有关。尽管有许多治疗选择，但它具有很高的持久性和复发性。目的：介绍我们通过微喉镜切除和肉毒杆菌毒素注射治疗复发性接触性肉芽肿的经验。设计：案例系列。随访期平均为41（11-88）个月。地点：大专转诊大学诊所。参与者：20例复发，3级和4级接触性肉芽肿患者，其保守治疗失败后至少切除了一次病变。干预措施：将显微喉镜切除术和A型肉毒杆菌毒素注射到双侧甲状腺和外侧环缝肌肉的区域。主要结果和措施：接触性肉芽肿消失。结果：17例接触性肉芽肿治愈。三名患者复发：2名门诊患者仅接受肉毒杆菌毒素注射并recovered愈。另一位患者在全身麻醉下需要切除并重新注射。这3例患者在最后一次随访中均未见肉芽肿。结论与相关性：保守治疗失败后，显微喉镜切除术和A型肉毒毒素注射液成功治疗了复发性接触性肉芽肿。如果在切除时添加A型肉毒杆菌毒素，则切除复发性肉芽肿可导致较低的复发率。

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