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首页> 外文期刊>Circulation journal >Virtual histology findings and effects of varying doses of atorvastatin on coronary plaque volume and composition in statin-naive patients - The VENUS study -
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Virtual histology findings and effects of varying doses of atorvastatin on coronary plaque volume and composition in statin-naive patients - The VENUS study -

机译：虚拟组织学发现和不同剂量的阿托伐他汀对未接受他汀类药物的患者冠状动脉斑块体积和组成的影响-VENUS研究-

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Background: While statin induces plaque regression, its effects, particularly with different doses on plaque virtual histology composition, remain unknown. Methods and Results: In this prospective, randomized, double-blinded study, 40 consecutive statin-naive patients with stable angina requiring percutaneous coronary intervention (PCI) were randomized to 2 arms (20 patients each) receiving 6 months of atorvastatin 10 mg or 40 mg daily. The primary end-point was (VH-IVUS) changes from baseline to 6 months, as assessed by a core laboratory. Fifty-four VH-IVUS lesions were analyzed from the 10 mg group and 57 from the 40 mg group. Overall, plaque volume was reduced by 4.28% (-5.10±14.93 mm3, P0.001), absolute VH-IVUS fibrous volume by 10.54% (-4.87±10.74 mm3, P0.001), and relative percentage fibrous component by 3.29±7.84% (P0.001), while relative percentage dense calcium increased by 1.50±3.08% (P0.001), and necrotic core by 3.19±7.82% (P0.001). Beneficial changes were more substantial in the higher dose (40 mg) group, with significantly more percentage plaque volume regression (-1.50±3.85% vs. 0.38±4.05% increase in the 10 mg group, P=0.014), less relative percentage necrotic core expansion (1.68±7.57% vs. 4.78±7.82% in the 10 mg group, P=0.037), and without occurrence of major adverse cardiac events (vs. 6 patients in the 10 mg group, P=0.020). Conclusions: In statin-naive patients requiring PCI, 6 months of atorvastatin induced a significant percentage of plaque volume reduction and substantial modification of VH-IVUS composition. In addition, these effects appeared to vary with different doses of atorvastatin, showing significantly better limitation of relative percentage necrotic core expansion at a higher dose.
机译：背景：尽管他汀类药物可引起斑块消退，但其作用，尤其是不同剂量对斑块虚拟组织学成分的作用仍未知。方法和结果：在这项前瞻性，随机，双盲研究中，将40例需要经皮冠状动脉介入治疗（PCI）的稳定型心绞痛的连续未接受他汀类药物的患者随机分为2组（每组20名患者），接受6个月阿托伐他汀10 mg或40每天一次。核心实验室评估的主要终点是从基线到6个月的（VH-IVUS）变化。分析了10 mg组的54个VH-IVUS病变和40 mg组的57个。总体上，斑块体积减少了4.28％（-5.10±14.93 mm3，P <0.001），VH-IVUS纤维绝对体积减少了10.54％（-4.87±10.74 mm3，P <0.001），纤维成分的相对百分比减少了3.29± 7.84％（P <0.001），而致密钙的相对百分比增加1.50±3.08％（P <0.001），坏死核心增加3.19±7.82％（P <0.001）。较高剂量（40 mg）组的有益变化更为显着，斑块体积消退百分比显着更高（-1.50±3.85％，而10 mg组增加0.38±4.05％，P = 0.014），坏死相对百分率较小核心扩张（10 mg组为1.68±7.57％，4.78±7.82％，P = 0.037），并且没有发生严重的不良心脏事件（10 mg组为6名患者，P = 0.020）。结论：在未接受他汀类药物治疗的需要PCI的患者中，阿托伐他汀治疗6个月可显着减少斑块体积，并显着改变VH-IVUS的组成。另外，这些作用似乎随着不同剂量的阿托伐他汀而变化，显示出在较高剂量下坏死核心相对膨胀百分比的明显更好的限制。

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