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首页> 外文期刊>Journal of Analytical Toxicology >Detection of bumetanide in an over-the-counter dietary supplement.
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Detection of bumetanide in an over-the-counter dietary supplement.

机译：非处方膳食补充剂中布美他尼的检测。

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Bumetanide is a loop diuretic used clinically to treat heart failure, acute renal failure, high blood pressure, and edema. However, diuretics may also be used by athletes as masking agents and to decrease weight. Taken as masking agents, diuretics increase urine production and decrease urinary concentrations of banned performance-enhancing agents, such as anabolic steroids. StarCaps is an over-the-counter dietary supplement marketed as a diet aid. The manufacturer claims that the product contains only natural cleansing agents and emphasizes that it is free from traditional appetite suppressants such as sympathomimetic amines. However, no such disclaimer is made concerning diuretic agents. A single StarCaps capsule was administered to two male and two female volunteers, and their urine specimens were collected at discrete intervals (2, 4, 8, and 12 h) post administration. The specimens were analyzed by a high-performance liquid chromatography-mass spectrometry quadrupole (HPLC-MS) method, and bumetanidewas detected in all specimens (4.6 to 351.3 ng/mL). Adjusting the bumetanide concentrations for creatinine content did little to normalize the excretion profiles. Bumetanide was also detected in the StarCaps capsules at concentrations approaching therapeutic doses. HPLC-quadrupole-time-of-flight mass spectrometry was used to confirm the presence of bumetanide in the urine samples and StarCaps capsules. The results showed that unregulated dietary supplements may put consumers at risk for unwitting consumption of prescription medications, and that it is possible for athletes to inadvertently test positive for bumetanide and face disciplinary actions.
机译：布美他尼是临床上用于治疗心力衰竭，急性肾衰竭，高血压和水肿的。利尿剂。然而，利尿剂也可以被运动员用作掩蔽剂并减轻体重。利尿剂被用作掩蔽剂，可增加尿液的产生，并降低禁用的性能增强剂（如合成代谢类固醇）的尿液浓度。 StarCaps是一种非处方饮食补充剂，可作为减肥食品销售。制造商声称该产品仅包含天然清洁剂，并强调该产品不含传统的食欲抑制剂，例如拟交感神经胺。但是，没有关于利尿剂的免责声明。分别对两名男性和两名女性志愿者施用一个StarCaps胶囊，并在施用后的不连续间隔（2、4、8和12小时）收集他们的尿液标本。通过高效液相色谱-质谱四极杆（HPLC-MS）方法分析样品，并在所有样品中检出布美他尼（4.6至351.3 ng / mL）。调整布美他尼浓度的肌酐含量并不能使排泄曲线正常化。在StarCaps胶囊中还检测到了布美他尼，其浓度接近治疗剂量。 HPLC-四极杆飞行时间质谱用于确认尿液样品和StarCaps胶囊中存在布美他尼。结果表明，无节制的膳食补充剂可能使消费者面临不知不觉地服用处方药的风险，并且运动员可能会无意中检测出布美他尼呈阳性并面临纪律处分。

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