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首页> 外文期刊>Journal of Andrology >Increased risk of benign prostatic enlargement among patients with liver cirrhosis: a nationwide population-based study.
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Increased risk of benign prostatic enlargement among patients with liver cirrhosis: a nationwide population-based study.

机译：肝硬化患者中前列腺增生的风险增加：一项基于人群的全国性研究。

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There have been several post mortem studies focusing on the association between liver cirrhosis and benign prostate hyperplasia; however, the results are controversial. The aim of this study was to estimate the risk of benign prostatic enlargement during a 5-year follow-up period following a liver cirrhosis diagnosis, using nationwide population-based data and a retrospective cohort design. We used the "Longitudinal Health Insurance Database," derived from the Taiwan National Health Insurance program. The study cohort comprised 661 patients who had received treatment for liver cirrhosis between 1997 and 2001; the comparison cohort was composed of 3305 randomly selected patients. Stratified Cox proportional hazard regressions were performed as a means of comparing the 5-year benign prostatic enlargement survival rate for the 2 cohorts. Of the sampled patients, 808 patients (20.4%) developed benign prostatic enlargement during the follow-up period (ie, 163 individuals from the study cohort [24.7% of the patients with liver cirrhosis] and 645 individuals from the comparison cohort [19.5% of comparison cohort patients]). The log-rank test indicated that patients with liver cirrhosis had significantly lower 5-year benign prostatic enlargement-free survival rates than the controls (P < .001). The adjusted hazard ratios for benign prostatic enlargement following diagnosis with liver cirrhosis were 1.41 during the 5-year follow-up period. We conclude that the risk for benign prostatic enlargement increased after a diagnosis of liver cirrhosis. Further studies are needed to identify the underlying pathophysiology.
机译：验尸研究集中在肝硬化和前列腺增生之间的关系上。但是，结果是有争议的。这项研究的目的是使用全国范围内基于人群的数据和回顾性队列设计来评估肝硬化诊断后5年随访期间良性前列腺增大的风险。我们使用了源自台湾国民健康保险计划的“纵向健康保险数据库”。该研究队列包括661例在1997年至2001年期间接受过肝硬化治疗的患者。比较队列由3305名随机选择的患者组成。进行分层Cox比例风险回归分析，作为比较2个队列的5年前列腺增生生存率的一种方法。在样本患者中，有808例（20.4％）在随访期间出现了前列腺增生（即，研究队列中的163人[占肝硬化患者的24.7％]和对照队列中的645人[19.5％]）比较队列患者]]。对数秩检验表明，肝硬化患者的5年无前列腺良性前列腺肥大生存率显着低于对照组（P <.001）。在5年的随访期内，诊断为肝硬化后良性前列腺肥大的调整后风险比为1.41。我们得出的结论是，在诊断出肝硬化后，前列腺肥大的风险会增加。需要进一步的研究来确定潜在的病理生理。

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