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首页> 外文期刊>Japanese circulation journal >Strain difference in rats with experimental giant cell myocarditis.
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Strain difference in rats with experimental giant cell myocarditis.

机译：实验性巨细胞心肌炎大鼠的应变差异。

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摘要

Immunogenetic mechanisms may be involved in the pathogenesis of myocarditis and dilated cardiomyopathy. The present study investigated the incidence, histopathology and histocompatibility characteristics of experimental giant cell myocarditis in various strains of rats. Experimental giant cell myocarditis was induced by immunization with porcine cardiac myosin in Lewis (RT-1(l)), Dahl (DIR/Eis) (RT-1(l)), Fisher (RT-1(lv 1)) rats, but not in Dahl (DIS/Eis) (RT-1(l)) or Brown Norway (RT-1(n)). Myocarditis was most severe in the Lewis rats and their heart weight/body weight ratio was significantly higher than that of control rats immunized with Freund's complete adjuvant alone. In conclusion, this study provides evidence that the expression and severity of experimental giant cell myocarditis may be determined mainly by genetic factors, including both major histocompatibility complex genes as well as other genes, which may be controlled by an immune mechanism.
机译：免疫原性机制可能与心肌炎和扩张型心肌病的发病机制有关。本研究调查了各种大鼠实验性巨细胞心肌炎的发病率，组织病理学和组织相容性特征。实验性巨细胞心肌炎是通过在Lewis（RT-1（l）），Dahl（DIR / Eis）（RT-1（l）），Fisher（RT-1（lv 1））大鼠中用猪心脏肌球蛋白免疫诱导的，但不在达尔（DIS / Eis）（RT-1（l））或挪威布朗（RT-1（n））中。在Lewis大鼠中，心肌炎最严重，其心重/体重比显着高于仅用弗氏完全佐剂免疫的对照大鼠。总之，这项研究提供了证据，实验性巨细胞心肌炎的表达和严重程度可能主要由遗传因素决定，包括主要的组织相容性复合基因以及其他可能受免疫机制控制的基因。

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