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首页> 外文期刊>Japanese circulation journal >Sympathetic hyperactivity in patients with vasospastic angina--assessment by spectral analysis of heart rate and arterial pressure variabilities.
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Sympathetic hyperactivity in patients with vasospastic angina--assessment by spectral analysis of heart rate and arterial pressure variabilities.

机译：血管痉挛性心绞痛患者的交感神经亢进-通过心率和动脉压变异性的频谱分析评估。

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摘要

The autonomic nervous system may play an important role in regulating coronary arterial tone. To evaluate the role of autonomic nervous activity in patients with vasospastic angina (VSA), we studied 10 VSA patients with patent coronary artery (mean; 56 yr, range; 44-66 yr) and 8 normal subjects (mean; 58 yr, range; 35-71 yr). ECG and arterial pressure were continuously recorded for 4 min in a supine position at 7:30 am, 10:30 am, and 4:30 pm. Low-frequency (LF; 0.04-0.15 Hz) and high-frequency (HF; 0.20 Hz) components of the beat-to-beat variabilities of the R-R interval (RRI) and systolic arterial pressure (SAP) were then estimated by autoregressive power spectral analysis. The LF-Normalized Power (LF-NP; [LF Power]/[Total Power]-[Direct Current Power]) of both the RRI and SAP variabilities were greater in VSA patients than in normal subjects (RRI: 0.51 +/- 0.07, 0.51 +/- 0.07, 0.53 +/- 0.06, vs 0.25 +/- 0.04, 0.31 +/- 0.05, 0.31 +/- 0.06, at 7:30 am, 10:30 am, and 4:30 pm respectively: p = 0.010, 0.044, 0.018. SAP: 0.62 +/- 0.06, 0.53 +/- 0.06, 0.57 +/- 0.06 vs 0.37 +/- 0.04, 0.30 +/- 0.06, 0.26 +/- 0.07, respectively: p = 0.006, 0.017, 0.003.). The LF-power of SAP variability also tended to be greater in VSA patients. There was no difference in the HF-component coefficient of variance (CCV (%) = 100 x (component power) (1/2)/ mean RR intervals) of the RRI variabilities between the 2 groups. These results indicate that increased sympathetic vasomotor tone and cardiac sympathetic predominance may play an important role in patients with VSA.
机译：自主神经系统可能在调节冠状动脉张力中起重要作用。为了评估自主神经活动在血管痉挛性心绞痛（VSA）患者中的作用，我们研究了10例冠状动脉未闭的VSA患者（平均; 56岁，范围; 44-66岁）和8名正常受试者（平均; 58岁，范围） ; 35-71年）。在7:30 am，10：30 am和4:30 pm仰卧位连续4分钟记录心电图和动脉压。然后通过自回归功率估算RR间隔（RRI）的搏动变化的低频（LF; 0.04-0.15 Hz）和高频（HF; 0.20 Hz）分量光谱分析。 VSA患者的RRI和SAP变异性的LF归一化功率（LF-NP; [LF功率] / [总功率]-[直流功率]）均比正常受试者大（RRI：0.51 +/- 0.07分别在上午7:30，上午10:30和下午4:30分别为0.51，+ /-0.07、0.53 +/- 0.06和0.25 +/- 0.04、0.31 +/- 0.05、0.31 +/- 0.06： p = 0.010、0.044、0.018.SAP：0.62 +/- 0.06、0.53 +/- 0.06、0.57 +/- 0.06和0.37 +/- 0.04、0.30 +/- 0.06、0.26 +/- 0.07：p = 0.006、0.017、0.003。）。在VSA患者中，SAP变异的LF功效也倾向于更大。两组之间的RRI变异性的HF分量方差系数（CCV（％）= 100 x（分量功率）（1/2）/平均RR间隔）没有差异。这些结果表明，增加的交感性血管舒缩张力和心脏的交感优势在VSA患者中可能起重要作用。

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