Structure-activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor.

Pontillo J; Tran JA; White NS; Arellano M; Fleck BA; Marinkovic D; Tucci FC; Saunders J; Foster AC; Chen C

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Structure-activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor.

机译：结构-活性关系研究一系列的环己基哌嗪带有人乙酰基皮质醇4受体的配基乙酰胺。

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摘要

Synthesis and structure-activity relationship studies of a series of cyclohexylpiperazines bearing an amide side chain as ligands of the MC4 receptor are discussed. Compounds such as 11i from this series are potent agonists (EC(50)=33nM, IA=96%).

机译：讨论了一系列带有酰胺侧链作为MC4受体配体的环己基哌嗪的合成及其构效关系。该系列的化合物，例如11i是有效的激动剂（EC（50）= 33nM，IA = 96％）。

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《Bioorganic and Medicinal Chemistry Letters》 |2005年第23期|共4页
作者
Pontillo J; Tran JA; White NS; Arellano M; Fleck BA; Marinkovic D; Tucci FC; Saunders J; Foster AC; Chen C;
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正文语种 eng
中图分类基础医学;
关键词
melanocortin 4 receptor; Bears; Human; Synthesis; structure; 熊;

机译：黑皮质素4受体;熊;人类;合成;结构;熊;

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1. Structure-activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor. [J] . Pontillo J, Tran JA, White NS, Bioorganic and Medicinal Chemistry Letters . 2005,第23期

机译：结构-活性关系研究一系列的环己基哌嗪带有人乙酰基皮质醇4受体的配基乙酰胺。
2. Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands. [J] . Marinkovic D, Tucci FC, Tran JA, Bioorganic and Medicinal Chemistry Letters . 2008,第17期

机译：一系列哌嗪苄醇及其酮和胺类似物作为黑皮质素4受体配体的结构活性关系研究。
3. Quantitative structure-activity relationship studies of a series of non-benzodiazepine structural ligands binding to benzodiazepine receptor. [J] . Xia B, Ma W, Zheng B, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2008,第7期

机译：一系列与苯并二氮杂receptor受体结合的非苯并二氮杂structural结构配体的定量构效关系研究。
4. Discovery of a Ligand that Compensates for Decreased Endogenous Agonist Potency of Melanocortin-4 Receptor Polymorphisms Identified in Obese Humans [C] . Carrie Haskell-Luevano, Zhimin Xiang, Andrzej M. Wilczynski American Peptide Symposium . 2009

机译：发现肥胖人类中鉴定的黑素旋蛋白-4受体多态性的内源性激动剂效力降低的配体的发现
5. Structure-activity relationships of ruthenium(II) polypyridyl complexes with redox-active intercalating ligands: Correlation between redox activity, DNA cleavage capability and cytotoxicity. [D] . Narh, Eugenia Soyo. 2015

机译：钌（II）聚吡啶基配合物与氧化还原活性的嵌入配体的结构活性关系：氧化还原活性，DNA裂解能力和细胞毒性之间的相关性。
6. Two- and Three-Dimensional Quantitative Structure-Activity Relationships Studies on a Series of Liver X Receptor Ligands [O] . Káthia M Honório, Lívia B Salum, Richard C Garratt, 2008

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7. Two- and Three-Dimensional Quantitative Structure-Activity Relationships Studies on a Series of Liver X Receptor Ligands [O] . Honório, Káthia M, Salum, Lívia B, Garratt, Richard C, 2008

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8. Novel Approach to the Use of Graph Theory in Structure-Activity Relationship Studies. Application to the Qualitative Evaluation of Mutagenicity in a Series of Nonfused Ring Aromatic Compounds [R] . Klopman, G., Raychaudhury, C. 1988

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Structure-activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor.

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