A new monoclonal anti-idiotypic catalytic antibody with a CPA-like activity.

Du M; Guo Z; Jin S

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A new monoclonal anti-idiotypic catalytic antibody with a CPA-like activity.

机译：具有CPA样活性的新型单克隆抗独特型催化抗体。

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IIF9D8, a new monoclonal anti-idiotypic catalytic antibody with a CPA esterase-like activity was elicited by ID11D7, the monoclonal competitive inhibitory antibody to CPA. The hydrolysis of hippuryl-DL-phenyllactic acid by McAb IIF9D8 follows the Michaelis-Menten kinetics. The Km value and kcat are 0.036 M and 0.598 min(-1), respectively, and the rate acceleration (kcat/kuncat) is 30500. Compared with the previous McAb 32C3 induced by polyclonal antibodies to CPA, McAb IIF9D8 shows higher catalytic efficiency The catalytic antibodies with the catalytic properties similar to natural enzymes could be obtained by this approach.

机译：IIF9D8是一种新的具有CPA酯酶样活性的单克隆抗独特型催化抗体，它是由ID11D7（一种抗CPA的竞争性竞争抗体）引发的。 McAb IIF9D8水解马来酰-DL-苯基乳酸的过程遵循Michaelis-Menten动力学。 Km值和kcat分别为0.036 M和0.598 min（-1），速率加速（kcat / kuncat）为30500。与先前针对CPA的多克隆抗体诱导的McAb 32C3相比，McAb IIF9D8显示出更高的催化效率。通过这种方法可以获得具有类似于天然酶的催化特性的催化抗体。

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《Bioorganic and Medicinal Chemistry Letters》 |1999年第11期|共6页
作者
Du M; Guo Z; Jin S;
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正文语种 eng
中图分类药学;生物化学;
关键词
Antibodies; Anti-Idiotypic; Antibodies; Catalytic; Antibodies; Monoclonal; 抗体; 抗独特型; 抗体; 催化; 抗体; 单克隆; 羧肽酶类;

机译：Antibodies;Anti-Idiotypic;Antibodies;Catalytic;Antibodies;Monoclonal;抗体;抗独特型;抗体;催化;抗体;单克隆;羧肽酶类;

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1. A new monoclonal anti-idiotypic catalytic antibody with a CPA-like activity. [J] . Du M, Guo Z, Jin S Bioorganic and Medicinal Chemistry Letters . 1999,第11期

机译：具有CPA样活性的新型单克隆抗独特型催化抗体。
2. A quantitative human monoclonal antibody immunoassay using anti-idiotypic antibody as a membrane antigen surrogate with surface-plasmon-resonance detection [J] . Wong RB, Lee AH, Rangan VS, Biotechnology and Applied Biochemistry . 2009,第Pta1期

机译：使用抗独特型抗体作为膜抗原替代品的表面等离子体共振检测定量人类单克隆抗体免疫测定
3. Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies. [J] . Hall TR, Bogdani M, Leboeuf RC, Immunology: An Official Journal of the British Society for Immunology . 2008,第4期

机译：GAD65特异性单克隆抗体对NOD小鼠中糖尿病的调节是表位特异性的，并伴有抗独特型抗体。
4. Recombinant Anti-Idiotypic Antibodies for Antibody Drug Development [C] . Achim Knappik, Francisco Ylera, Christian Frisch, PEGS . 2014

机译：重组抗独特型抗体抗体药物发育
5. Characterization of Anti-Ricin Monoclonal Antibodies and the Construction of a Chimeric Murine-Human IgG2/K Anti-Ricin Monoclonal Antibody [D] . Vendramelli, Robert Matthew 2011

机译：抗蓖麻毒蛋白单克隆抗体的表征和鼠/人IgG2 / K嵌合抗蓖麻毒蛋白单克隆抗体的构建
6. Monoclonal anti-idiotypic antibodies as functional internal images of enzyme active sites: production of a catalytic antibody with a cholinesterase activity. [O] . L Izadyar, A Friboulet, M H Remy, 1993

机译：单克隆抗独特型抗体作为酶活性位点的功能内部图像：具有胆碱酯酶活性的催化抗体的产生。
7. Monoclonal anti-idiotypic antibodies as functional internal images of enzyme active sites: production of a catalytic antibody with a cholinesterase activity. [O] . Izadyar, L, Friboulet, A, Remy, M H, 1993

机译：单克隆抗独特型抗体，作为酶活性位点的功能内部图像：具有胆碱酯酶活性的催化抗体的产生。
8. Synthesis of Phosphorus Based Haptens for Monoclonal Catalytic Antibody Production. Phase 2. [R] . Liu, K., Tuladhar, S. T. 1995

机译：单克隆催化抗体生产用磷基硫酸酯的合成。阶段2。

A new monoclonal anti-idiotypic catalytic antibody with a CPA-like activity.

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