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首页> 外文期刊>Journal of Applied Polymer Science >pH-sensitive shrinking of a dextran sulfate/chitosan complex gel and its promotion effect on therelease of polymeric substances
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pH-sensitive shrinking of a dextran sulfate/chitosan complex gel and its promotion effect on therelease of polymeric substances

机译：硫酸葡聚糖/壳聚糖复合凝胶的pH敏感收缩及其对聚合物释放的促进作用

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摘要

A pH-sensitive gel was prepared by polyelectrolyte complex formation between dextran sulfate and chitosan. When the complex gel contained more aminogroups than sulfate groups, it shrank pronouncedly at around pH 7 in NaCl solutions of various concentrations, probably because of the deionization of protonated amino groups remaining free from electrostatic interaction with the sulfate groups. Using the complex gel loaded with dextran by absorption, releasing behaviors were studied under various conditions. It was shown that shrinking of the complex gel had a promotion effect on the release of dextran. In 170 mM NaCI solution, the complex gel released dextran more rapidly at pH 8 than at pH 2, because the degree of shrinking was greater at pH 8. Thus, the promotion effect of the complex gel on the release of dextran was pH dept~ndent, though the release rates at the two pHs became closer as the average molecular weight of dextran loaded was lowered.
机译：通过在硫酸葡聚糖和壳聚糖之间形成聚电解质复合物来制备pH敏感凝胶。当复合凝胶包含的氨基比硫酸根更多时，在各种浓度的NaCl溶液中，pH在7左右时都会明显收缩，这可能是由于质子化氨基的去离子作用所致，而该离子没有与硫酸根发生静电相互作用。使用通过吸收负载有葡聚糖的复合凝胶，研究了在各种条件下的释放行为。结果表明，复合凝胶的收缩对葡聚糖的释放具有促进作用。在170 mM NaCl溶液中，复合物凝胶在pH 8时比在pH 2时释放得更快，因为在pH 8时收缩程度更大。因此，复合物凝胶对葡聚糖释放的促进作用是pH dept〜。 ndent，尽管随着加载的葡聚糖的平均分子量降低，在两个pH下的释放速率变得更接近。

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