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首页> 外文期刊>Journal of Applied Polymer Science >Synthesis and characterization of degradable copoly(trans-4-hydroxy-L-proline/epsilon-caprolactone)
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Synthesis and characterization of degradable copoly(trans-4-hydroxy-L-proline/epsilon-caprolactone)

机译：可降解共聚（反式-4-羟基-L-脯氨酸/ε-己内酯）的合成与表征

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The melt polycondensation reaction of N-protected trans-4-hydroxy-L-proline (N-Z-Hpr) and E-caprolactone (E-CL) over a wide range of molar fractions in the feed produced new and degradable poly(N-Z-Hpr-co-epsilon-CL)s with stannous octoate as a catalyst. The optimal reaction conditions for the synthesis of the copolymers were obtained with 1.5 wt % stannous octoate at 140degreesC for 24 h. The synthesized copolymers were characterized by IR spectrophotometry, H-1 NMR, differential scanning calorimetry, and Ubbelohde viscometry. The values of the inherent viscosity and glass-transition temperature (T-g) of the copolymers depended on the molar fractions of N-Z-Hpr. With an increase in the trans-4-hydroxy-N-benzyloxycarbonyl-L-proline (N-CBz-Hpr) feed from 10 to 90 mol %, a decrease in eta(inh) from 2.47 to 1.05 dL/g, and an increase in T-g from -48 to 49degreesC were observed. The in vitro degradation of these poly(N-CBz-Hpr-co-epsilon-CL)s was evaluated from weight-loss measurements. (C) 2003 Wiley Periodicals, Inc. [References: 22]
机译：N-保护的反式-4-羟基-L-脯氨酸（NZ-Hpr）和E-己内酯（E-CL）在进料中大范围的摩尔分数上的熔融缩聚反应产生了可降解的新型聚（NZ-Hpr） -co-ε-CL）s与辛酸亚锡作为催化剂。用140重量％的辛酸亚锡在140℃下24小时获得用于合成共聚物的最佳反应条件。合成的共聚物通过红外分光光度法，H-1 NMR，差示扫描量热法和乌氏粘度法进行表征。共聚物的特性粘度和玻璃化转变温度（T-g）的值取决于N-Z-Hpr的摩尔分数。随着反式-4-羟基-N-苄氧基羰基-L-脯氨酸（N-CBz-Hpr）的进料从10 mol％增加到90 mol％，eta（inh）从2.47 dL / g降低，并且观察到Tg从-48增加到49℃。这些聚（N-CBz-Hpr-co-ε-CL）的体外降解是通过减肥测定来评估的。 （C）2003 Wiley Periodicals，Inc. [参考：22]

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