In vitro stability of alpha-Helical peptide nucleic acids (alphaPNAs).

Garner P; Sherry B; Moilanen S; Huang Y

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In vitro stability of alpha-Helical peptide nucleic acids (alphaPNAs).

机译：α-螺旋肽核酸（alphaPNAs）的体外稳定性。

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alpha-Helical peptide nucleic acids (alphaPNAs) are synthetic molecules that merge the alpha-helix secondary structure of peptides with the codified Watson-Crick base pairing capability of nucleic acids. It is now demonstrated that alphaPNAs made up of either L- or D-amino acids are resistant to degradation by the proteases present in human serum. The increased stability of alphaPNAs towards proteases may be attributable to the presence of unnatural nucleoamino acid residues [-NHCH(CH(2)OCH(2)B)CO-, where B=thymine or cytosine] since the replacement of these amino acids by serine yields a control peptide that does break down in human serum. The stability of alphaPNAs towards proteases makes them attractive candidates for further development as antisense agents.

机译：α-螺旋肽核酸（alphaPNAs）是将肽的α-螺旋二级结构与核酸的编码Watson-Crick碱基配对能力融合在一起的合成分子。现在证明，由L-或D-氨基酸组成的αPNA对人血清中存在的蛋白酶具有抗降解性。 alphaPNA对蛋白酶的稳定性提高可能归因于存在非天然核苷酸残基[-NHCH（CH（2）OCH（2）B）CO-，其中B =胸腺嘧啶或胞嘧啶]，因为这些氨基酸被丝氨酸产生确实在人血清中分解的对照肽。 αPNA对蛋白酶的稳定性使其成为反义剂进一步开发的有吸引力的候选对象。

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《Bioorganic and Medicinal Chemistry Letters》 |2001年第17期|共3页
作者
Garner P; Sherry B; Moilanen S; Huang Y;
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正文语种 eng
中图分类药学;生物化学;
关键词
Alpha; Peptide Nucleic Acids; Endopeptidases; 肽核酸类;

机译：Alpha;Peptide Nucleic Acids;Endopeptidases;肽核酸类;

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专利

1. In vitro stability of alpha-Helical peptide nucleic acids (alphaPNAs). [J] . Garner P, Sherry B, Moilanen S, Bioorganic and Medicinal Chemistry Letters . 2001,第17期

机译：α-螺旋肽核酸（alphaPNAs）的体外稳定性。
2. Facile synthesis of peptide nucleic acids and peptide nucleic acid-peptide conjugates on an automated peptide synthesizer [J] . Rajendra Joshi, Deepti Jha, Wu Su, Journal of peptide science: An official publication of the European Peptide Society . 2011,第1期

机译：在自动肽合成仪上轻松合成肽核酸和肽核酸-肽结合物
3. Peptide nucleic acid and amino acid modified peptide nucleic acid analysis by capillary zone electrophoresis [J] . Wang Xiaoqian, Li Linsen, Khan Rizwan Ullah, Electrophoresis: The Official Journal of the International Electrophoresis Society . 2019,第7期

机译：肽核酸和氨基酸改性肽核酸分析毛细管区电泳
4. The determination of helix stability coefficients using D-amino acid substitutions in the non-polar face of an amphipathic alpha-helical model peptide [C] . Yuxin Chen, Colin T.Mant, Robert S.Hodges the International Peptide Symposium . 2001

机译：在两亲α-螺旋模型肽的非极性面上使用D-氨基酸取代的螺旋稳定系数的测定
5. Development of antisense alpha-helical peptide nucleic acids. [D] . Huang, Yumei. 2002

机译：反义α-螺旋肽核酸的开发。
6. Packing and hydrophobicity effects on protein folding and stability: effects of beta-branched amino acids, valine and isoleucine, on the formation and stability of two-stranded alpha-helical coiled coils/leucine zippers. [O] . B. Y. Zhu, N. E. Zhou, C. M. Kay, 2020

机译：堆积和疏水性对蛋白质折叠和稳定性的影响：β-支链氨基酸，缬氨酸和异亮氨酸对两链α-螺旋卷曲线圈/亮氨酸拉链的形成和稳定性的影响。
7. Peptide Nucleic Acids Complexes of Two Peptide Nucleic Acid Strands and One [O] . Ecker David J., Buchardt Ole, Engholm Michael, 1999

机译：两种肽核酸链的肽核酸复合物和一种
8. In Vitro Assessment of a Peptide Nucleic Acid (PNA) - Peptide Conjugate Labeled With an Auger-Emitting Radionuclide for Prostate Cell Killing [R] . Wilbur, S. D. 2005

机译：体外评估肽核酸（pNa） - 用俄歇发射放射性核素标记的肽缀合物用于前列腺细胞杀伤

In vitro stability of alpha-Helical peptide nucleic acids (alphaPNAs).

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