Molecular dynamics for computational proteomics of methylated histone H3

Grauffel Cedric; Stote Roland H.; Dejaegere Annick

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Molecular dynamics for computational proteomics of methylated histone H3

机译：甲基化组蛋白H3计算蛋白质组学的分子动力学

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Background: Post-translational modifications of histones, and in particular of their disordered N-terminal tails, play a major role in epigenetic regulation. The identification of proteins and proteic domains that specifically bind modified histones is therefore of paramount importance to understand the molecular mechanisms of epigenetics.

机译：背景：组蛋白的翻译后修饰，尤其是其无序的N末端尾巴，在表观遗传调控中起主要作用。因此，识别与修饰的组蛋白特异性结合的蛋白质和蛋白质结构域对于理解表观遗传学的分子机制至关重要。

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《Biochimica et Biophysica Acta. General Subjects》 |2015年第5期|共15页
作者
Grauffel Cedric; Stote Roland H.; Dejaegere Annick;
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正文语种 eng
中图分类生物化学;
关键词
Molecular dynamics; Protein interaction; Histone; Proteomics; Epigenetics;

机译：分子动力学;蛋白质相互作用;组蛋白;蛋白质组学;表观遗传学;
入库时间 2022-08-18 09:01:41

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1. Molecular dynamics for computational proteomics of methylated histone H3 [J] . Grauffel Cedric, Stote Roland H., Dejaegere Annick Biochimica et Biophysica Acta. General Subjects . 2015,第5期

机译：甲基化组蛋白H3计算蛋白质组学的分子动力学
2. Towards a Molecular Understanding of the Silencing of Transcription by Heterochromatin: Methylation of Histone H3 Lysine 9 Creates a Binding Site for HP1 Proteins Selective Recognition of Methylated Lysine 9 on Histone H3 by the HP1 Chromo Domain Rol [J] . M. Lachner, D. OCarroll, S. Rea, Chemtracts . 2001,第10期

机译：对通过异染色质沉默转录的分子理解：组蛋白H3赖氨酸9的甲基化为HP1蛋白形成结合位点通过组蛋白H1色域Rol对组蛋白H3的甲基化赖氨酸9进行选择性识别。
3. Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter [J] . Kim Jinho, Lee Sung-Hun, Jang Ji Hwan, Journal of neurosurgery. . 2017,第5期

机译：组蛋白H3赖氨酸4甲基转移酶MLL4的表达和组蛋白H3赖氨酸27脱甲基酶UTX延长了胶质母细胞瘤患者的整体存活和甲基化MGMT启动子
4. Detailed Structural Characterization of Recombinant Histone H3 and Its Methylated Analogs by Top-down ESI-FTMS [C] . Jun Han, Christoph H. Borchers American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：通过自上而下的ESI-FTMS重组组蛋白H3及其甲基化类似物的详细结构表征
5. Understanding of Histone H3 Phosphorylation and Acetylation on Enhancement of the Soybean Tolerance to Salinity Via Proteomic Profile. [D] . Pi, Erxu. 2012

机译：通过蛋白质组学了解组蛋白H3磷酸化和乙酰化对提高大豆对盐分耐受性的影响。
6. EPIG-07PROGNOSTIC ROLE OF HISTONE H3 LYSINE 27 DEMETHYLASE (UTX) AND HISTONE H3 LYSINE 4 METHYLTRANSFERASE (MLL4) ON THE GLIOBLASTOMA PATIENTS WITH METHYLATED MGMT PROMOTER [O] . Jinho Kim, Ji Hwan Jang, Young Min Lee, 2015

机译：EPIG-07组氨酸H3赖氨酸27去甲基化酶（UTX）和组蛋白H3赖氨酸4甲基转移酶（MLL4）在具有甲基化MGMT启动子的胶质母细胞瘤患者中的作用
7. EPIG-07PROGNOSTIC ROLE OF HISTONE H3 LYSINE 27 DEMETHYLASE (UTX) AND HISTONE H3 LYSINE 4 METHYLTRANSFERASE (MLL4) ON THE GLIOBLASTOMA PATIENTS WITH METHYLATED MGMT PROMOTER [O] . Jinho Kim, Ji Hwan Jang, Young Min Lee, 2015

机译：EPIG-07组蛋白H3赖氨酸27去甲基酶（UTX）和组蛋白H3赖氨酸4甲基转移酶（MLL4）的甲基化MGMT启动子

Molecular dynamics for computational proteomics of methylated histone H3

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