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首页> 外文期刊>Journal of applied toxicology >Pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells
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Pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells

机译：五氯酚降低人自然杀伤细胞的肿瘤细胞结合能力和细胞表面蛋白表达

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摘要

Pentachlorophenol (PCP) is an organochlorine pesticide that decreases the tumor-cell killing (lytic) function of human natural killer (NK) cells. NK cells defend against tumor cells and virally infected cells. They bind to these targets, utilizing a variety of cell-surface proteins. This study examined concentrations of PCP that decrease lytic function for alteration of NK binding to tumor targets. Levels of PCP that caused loss of binding function were then examined for effects on expression of cell-surface proteins needed for binding. Exposure to 10μm PCP for 24h (which caused a greater than 70% loss of lytic function) decreased NK binding function (34.6%), and CD11a (21.7%) and CD56 (26.2%) cell-surface proteins. Both binding function and cell-surface proteins were decreased after longer exposures to lower concentrations of PCP. These data indicate that continuous exposures to PCP decreased binding function as well as cell-surface marker expression in NK cells and that these changes may in part explain the losses of lytic function seen with these exposures. PCP exposures have been shown to increase the incidence of blood and kidney cancers in humans. These data indicate that a possible explanation for this increased risk may be loss of NK lytic function, which is at least in part owing to the loss of the ability of the NK cell to bind to tumor cells. These data also indicate that lost binding function may be due to loss of important cell-surface proteins.
机译：五氯苯酚（PCP）是一种有机氯农药，可降低人类自然杀伤（NK）细胞对肿瘤细胞的杀灭（裂解）功能。 NK细胞防御肿瘤细胞和病毒感染的细胞。它们利用多种细胞表面蛋白与这些靶标结合。这项研究检查了PCP的浓度，这些浓度会降低裂解功能，从而改变NK与肿瘤靶标的结合。然后检查引起结合功能丧失的PCP水平对结合所需的细胞表面蛋白表达的影响。暴露于10μmPCP达24h（导致裂解功能损失超过70％）会降低NK结合功能（34.6％）以及CD11a（21.7％）和CD56（26.2％）细胞表面蛋白。长时间暴露于较低浓度的PCP后，结合功能和细胞表面蛋白均降低。这些数据表明，连续暴露于PCP会降低NK细胞的结合功能以及细胞表面标志物的表达，并且这些变化可能部分解释了这些暴露所导致的裂解功能丧失。研究表明，五氯苯酚的暴露会增加人类血液和肾脏癌的发病率。这些数据表明，这种风险增加的可能解释可能是NK裂解功能丧失，这至少部分是由于NK细胞与肿瘤细胞结合的能力丧失所致。这些数据还表明丧失的结合功能可能是由于重要的细胞表面蛋白的丧失。

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