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首页> 外文期刊>Journal of applied toxicology >Absorption, disposition and metabolism of di-isononyl phthalate (DINP) in F-344 rats.
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Absorption, disposition and metabolism of di-isononyl phthalate (DINP) in F-344 rats.

机译：邻苯二甲酸二异壬酯（DINP）在F-344大鼠中的吸收，处置和代谢。

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Di-isononyl phthalate (DINP; CAS no. 68515-48-0) is a general-purpose plasticizer for polyvinyl chloride. It produced liver and kidney effects when given to rodents at high oral doses, but there were no target organ effects in primates treated under similar conditions. To assist in understanding the basis for these species differences, the pharmacokinetic properties of DINP were evaluated in rodents following both oral and dermal administration. These studies demonstrated that the pharmacokinetic properties of DINP are similar to those of other high-molecular-weight phthalates. When orally administered to rodents, DINP is rapidly metabolized in the gastrointestinal tract to the corresponding monoester, absorbed and excreted, primarily in the urine. Shortly after administration, DINP is found primarily in liver and kidneys, but it does not persist or accumulate in any organ or tissue. It is very poorly absorbed from the skin, but once absorbed it behaves in the same way as the orally administered material. The results of these rodent studies contrast with data from studies involving humans or other primates, which indicate low absorption at low oral doses and much more limited total absorption at high doses. It appears that many, if not all, of the effects of DINP in rodent studies are associated with internal doses that would be difficult, if not impossible, to achieve in humans under any circumstances. Thus, the results of rodent studies may not be very useful in assessing the potential risks to humans from high-molecular-weight phthalates.
机译：邻苯二甲酸二异壬酯（DINP; CAS编号68515-48-0）是一种用于聚氯乙烯的通用增塑剂。当以高剂量口服给啮齿动物时，它会产生肝脏和肾脏的作用，但是在类似条件下处理的灵长类动物中没有靶器官的作用。为了帮助理解这些物种差异的基础，在口服和皮肤给药后，在啮齿动物中评估了DINP的药代动力学特性。这些研究表明，DINP的药代动力学特性与其他高分子量邻苯二甲酸酯相似。当口服给予啮齿动物时，DINP在胃肠道中迅速代谢为相应的单酯，主要在尿液中被吸收和排泄。给药后不久，DINP主要在肝脏和肾脏中发现，但不会持续存在或在任何器官或组织中积累。它很难从皮肤吸收，但是一旦吸收，其行为与口服材料相同。这些啮齿动物研究的结果与涉及人类或其他灵长类动物的研究数据形成对比，后者表明低剂量口服低吸收，而高剂量总吸收更有限。似乎在啮齿动物研究中，即使不是全部，DINP的许多作用与内部剂量有关，即使在任何情况下，如果不是不可能的话，内部剂量也很难实现。因此，啮齿动物研究的结果在评估高分子量邻苯二甲酸酯对人类的潜在风险方面可能不是很有用。

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