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首页> 外文期刊>Journal of applied toxicology >Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre-exposure to lipopolysaccharide.
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Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre-exposure to lipopolysaccharide.

机译：秋水仙碱对大鼠的急性经口毒性：性别，媒介物基质和脂多糖预暴露的影响。

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The oral toxicity of a single administration by gavage (10, 20 or 30 mg kg(-1) body weight) of colchicine (COL) was determined in young, mature male and female Sprague-Dawley rats. The effect of COL was evaluated in the presence or absence of additional treatment variables that included vehicle and lipopolysaccharide (LPS) pre-exposure. The vehicle for COL was either Half and Half cream (H & H) or saline, and each group included pretreatment with either saline or a low, minimally toxic dose (83 microg kg(-1) body weight) of LPS. Colchicine toxicity in both male and female age-matched rats was characterized by progressively more severe dose-related clinical signs of toxicity. These included mortality, decreased body weight and feed intake during the first several days after dosing, with recovery thereafter in surviving animals. There were differences in the severity of the toxic response to COL between male and female rats. The most notable sex-related difference was in COL lethality. Female rats were two times more susceptible to the lethal effects of COL than male rats. Saline or H & H delivery vehicles did not result in any apparent qualitative or quantitative differences in COL toxicity. LPS pretreatment significantly potentiated COL lethality in both males and females, although the potentiation in males was greater than in females. LPS pretreatment modestly increased the COL induced anorexic effect in surviving males, but not in surviving female animals. LPS did not appear to modulate either the body weights or clinical signs of COL induced toxicity in surviving males or females. Copyright (c) 2007 John Wiley & Sons, Ltd.
机译：在年轻，成年的雄性和雌性Sprague-Dawley大鼠中，通过强饲秋水仙碱（COL）一次灌胃（体重分别为10、20或30 mg kg（-1））来确定口服毒性。在存在或不存在其他治疗变量的情况下评估COL的效果，这些变量包括媒介物和脂多糖（LPS）的预暴露。用于COL的媒介物是Half and Half Cream（H＆H）或盐水，每组都包括用盐水或低毒剂量（83 microg kg（-1）体重）的LPS进行预处理。在年龄匹配的雄性和雌性大鼠中秋水仙碱的毒性都以逐渐严重的剂量相关的毒性临床症状为特征。这些包括给药后头几天的死亡率，体重下降和采食量，此后在存活的动物中恢复。雌雄大鼠对COL的毒性反应的严重程度存在差异。与性别相关的最显着差异是COL致死率。雌性大鼠对COL致死作用的敏感性是雄性大鼠的两倍。盐水或H＆H运载工具对COL毒性没有造成任何明显的定性或定量差异。 LPS预处理可显着增强雄性和雌性的COL致死率，尽管雄性的增强程度大于雌性。 LPS预处理在存活的雄性动物中适度增加了COL诱导的厌食作用，但在存活的雌性动物中则没有。在存活的男性或女性中，LPS似乎并未调节体重或COL诱导的毒性的临床体征。版权所有（c）2007 John Wiley＆Sons，Ltd.

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