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首页> 外文期刊>Journal of applied toxicology >Neurobehavioral toxicity study of dibutyl phthalate on rats following in utero and lactational exposure.
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Neurobehavioral toxicity study of dibutyl phthalate on rats following in utero and lactational exposure.

机译：邻苯二甲酸二丁酯在子宫和哺乳期暴露后对大鼠的神经行为毒性研究。

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To investigate the neurobehavioral effects of dibutyl phthalate (DBP), an important endocrine disruptor known for reproductive toxicity, on rodent offspring following in utero and lactational exposure, pregnant Wistar rats were treated with DBP (0, 0.037, 0.111, 0.333 and 1% in the diet) from gestation day (GD) 6 to postnatal day (PND) 28, and selected developmental and neurobehavioral parameters of the offspring were measured. There were no significant effects of DBP on body weight gain of the dams during GD 6-20 or on the pups' ages of pinna detachment, incisor eruption or eye opening. Exposure to 1% DBP prolonged gestation period, decreased body weight in both male and female pups, depressed surface righting (PND 7) in male pups, shortened forepaw grip time (PND 10), enhanced spatial learning and reference memory (PND 35) in male pups. Exposure to 0.037% DBP also shortened forepaw grip time (PND 10), but inhibited spatial learning and reference memory in male pups. Sex x treatment effects were found in forepaw grip time (PND 10), spatial learning and reference memory, and the male pups appeared to be more susceptible than the females. However, all levels of DBP exposure did not significantly alter surface righting (PND 4), air righting (PND 16), negative geotaxis (PND 4 or 7), cliff avoidance (PND 7) or open field behavior (PND 28) in either sex. Overall, the dose level of DBP in the present study produced a few adverse effects on the neurobehavioral parameters, and it may alter cognitive abilities of the male rodent.
机译：为了研究邻苯二甲酸二丁酯（DBP）（一种以生殖毒性闻名的重要内分泌干扰物）对子宫和哺乳期暴露后啮齿动物后代的神经行为的影响，对妊娠Wistar大鼠进行DBP（0、0.037、0.111、0.333和1％饮食）从妊娠第6天（GD）至出生后第28天（PND），并测量了后代的选定发育和神经行为参数。在GD 6-20期间，DBP对大坝的体重增加或幼犬的耳廓脱离，门牙爆发或睁眼没有显着影响。暴露于1％的DBP会延长妊娠期，雄性和雌性幼崽体重下降，雄性幼崽的表面矫正低沉（PND 7），缩短前爪握紧时间（PND 10），增强空间学习和参考记忆（PND 35）雄性幼崽。暴露于0.037％的DBP也会缩短前爪抓地时间（PND 10），但会抑制雄性幼崽的空间学习和参考记忆。在前爪抓地时间（PND 10），空间学习和参考记忆中发现了性别x的治疗效果，雄性幼崽似乎比雌性更易感。但是，所有水平的DBP暴露均未显着改变两种情况下的表面矫正（PND 4），空气矫正（PND 16），负地轴（PND 4或7），避险（PND 7）或露天视野行为（PND 28）性别。总体而言，本研究中DBP的剂量水平对神经行为参数产生了一些不利影响，并且可能会改变雄性啮齿动物的认知能力。

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