...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied toxicology >Genetic polymorphisms in metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine
【24h】

Genetic polymorphisms in metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine

机译：2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶代谢的遗传多态性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Heterocyclic amines (HCAs) are naturally produced during common cooking processes for meats and fish. HCAs are metabolized by various enzymes, including cytochromes P450, N-acetyl transferases, and sulfotransferases, and their bioactivated metabolites are considered to bind to DNA or protein to show carcinogenic effects. More than 20 HCAs have been identified, of which 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is classified as 'reasonably anticipated to be a human carcinogen' to develop cancers in breast, colon and prostate. The purpose of this study was to evaluate human exposure levels of PhIP and to understand the role of genetic polymorphisms of enzymes on PhIP metabolism. Urine samples were collected from subjects (n=100) before 3-day meat-restricted diets. Subjects consumed grilled chicken, and their blood and urine were collected before and after the administration of the chickens to investigate genetic polymorphisms and PhIP levels. The mean PhIP levels were 4.22±0.12, 0.61±0.19 and 22.64±1.00pgml-1 in urine under normal conditions and before and after chicken administration, respectively. Among 21 Single-nucleotide polymorphisms (SNP) of CYP1A1, CYP1A2, NATs and UGTs investigated in this study, genotypic groups of CYP1A1/T6235C (MSP I) and CYP1A2/-2467delT showed significant differences in PhIP excretion (P0.05). These results suggest that genetic polymorphisms might affect PhIP metabolism, which could improve understanding of populations subject to PhIP-derived health risk.
机译：杂环胺（HCA）是在肉和鱼的常见烹饪过程中自然产生的。 HCA被各种酶代谢，包括细胞色素P450，N-乙酰基转移酶和磺基转移酶，并且它们的生物活化代谢物被认为与DNA或蛋白质结合以显示致癌作用。已鉴定出20多种HCA，其中2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶（PhIP）被归类为“合理预期是人类致癌物”，会发展为乳腺癌，结肠和前列腺。这项研究的目的是评估人类对PhIP的暴露水平，并了解酶的遗传多态性对PhIP代谢的作用。在禁食三天前从受试者（n = 100）收集尿液样本。受试者食用了烤鸡，并在施用鸡之前和之后收集了他们的血液和尿液，以研究遗传多态性和PhIP水平。在正常条件下和鸡给药前后，尿液中的平均PhIP水平分别为4.22±0.12、0.61±0.19和22.64±1.00pgml-1。在这项研究中研究的CYP1A1，CYP1A2，NAT和UGT的21个单核苷酸多态性（SNP）中，CYP1A1 / T6235C（MSP I）和CYP1A2 / -2467delT的基因型组表现出PhIP排泄的显着差异（P <0.05）。这些结果表明，遗传多态性可能会影响PhIP的代谢，从而可以提高对受PhIP衍生的健康风险的人群的了解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号