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首页> 外文期刊>Journal of applied toxicology >Microminipigs as a new experimental animal model for toxicological studies: comparative pharmacokinetics of perfluoroalkyl acids
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Microminipigs as a new experimental animal model for toxicological studies: comparative pharmacokinetics of perfluoroalkyl acids

机译：Microminipigs作为毒理学研究的新实验动物模型：全氟烷基酸的比较药代动力学

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In this study, we evaluated the efficacy of a novel minipig strain, the Microminipig (MMPig), as an animal model for studying the pharmacokinetics of a mixture of 10 perfluoroalkyl acids (PFAAs). After a single oral dose was given, we found that the blood depuration of PFAAs (blood t(1/2)), which we calculated using first-order elimination curves, ranged from 1.6 to 86.6days. Among the five body compartments analyzed, the liver was the greatest site of accumulation of perfluorooctanesulfonate and longer chain perfluorinated carboxylates such as perfluorodecanoic acid, perfluoroundecanoic acid and perfluorododecanoic acid. We observed an increasing accumulation trend of perfluorinated carboxylates in the organs associated with the fluorinated carbon chain length. The perfluorononanoic acid burden was the highest among the treated compounds 21days after a single exposure, as 29% of the given perfluorononanoic acid dose was accumulated in the tissues. The persistence of PFAAs in edible pig tissues even after 21days post-exposure raises concerns about the safety of swine products. This was the first study to use MMPigs to elucidate the pharmacokinetics of a group of environmental pollutants. We found that MMPigs could be excellent experimental animals for toxicological studies due to their easy handling, cost efficacy for target compounds and ease of waste treatment. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：在这项研究中，我们评估了新型微型猪株Microminipig（MMPig）作为研究10种全氟烷基酸（PFAAs）混合物药代动力学的动物模型的功效。给予单次口服剂量后，我们发现我们使用一阶消除曲线计算出的PFAAs血液纯净度（血液t（1/2））为1.6至86.6天。在所分析的五个车厢中，肝脏是全氟辛烷磺酸和较长链全氟羧酸盐（如全氟癸酸，全氟十一烷酸和全氟十二烷酸）积累的最大场所。我们观察到与氟化碳链长相关的器官中全氟羧酸盐的积累趋势不断增加。在单次接触后21天，全氟壬酸的负担量最高，因为29％的给定全氟壬酸剂量累积在组织中。即使暴露后21天，PFAA在可食猪组织中的持久性也引起了人们对猪产品安全性的担忧。这是首次使用MMPigs阐明一组环境污染物的药代动力学的研究。我们发现MMPigs易于处理，目标化合物具有成本效益并且易于废物处理，因此可以作为毒理学研究的优秀实验动物。版权所有（c）2015 John Wiley＆Sons，Ltd.

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