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首页> 外文期刊>Journal of applied toxicology >Effects of selected anticholinergics on acoustic startle response in rats.
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Effects of selected anticholinergics on acoustic startle response in rats.

机译：所选抗胆碱药对大鼠听觉惊吓反应的影响。

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The present study compared the effects of the anticholinergics aprophen hydrochloride, atropine sulfate, azaprophen hydrochloride, benactyzine hydrochloride, biperiden hydrochloride, diazepam, procyclidine hydrochloride, scopolamine hydrobromide and trihexyphenidyl hydrochloride on acoustic startle response in rats. Peak startle amplitude, latency to peak startle amplitude and prepulse inhibition following 100- and 120-dB tones were recorded 15 min following drug administration in food-restricted rats. Aprophen, atropine, azaprophen, benactyzine, biperiden and scopolamine significantly increased peak startle amplitude and decreased latency to peak startle amplitude following 100-dB pulses. In contrast, only biperiden increased peak startle amplitude following 120-dB pulses, whereas atropine and trihexyphenidyl decreased latency to peak startle amplitude following 120-dB pulses. Benactyzine decreased prepulse inhibition following both 100- and 120-dB pulses, whereas both biperiden and scopolamine decreased prepulse inhibition following 120-dB pulses. Acoustic startle response measures were effective in differentiating the effects of anticholinergic compounds. The comparison of drug effects on the acoustic startle response may be useful in selecting efficacious anticholinergic drug therapies with a minimal range of side-effects. In addition, these data may be useful in down-selecting the number of anticholinergic drugs that need to be tested in comparison studies involving more complex behavioral tests. Copyright 2001 John Wiley & Sons, Ltd.
机译：本研究比较了抗胆碱药盐酸盐酸阿布芬，硫酸阿托品，盐酸氮杂艾芬，盐酸贝尼西嗪，盐酸双哌啶，地西epa，盐酸环丙啶，东sco碱氢溴酸盐和盐酸三己基哌啶盐对声惊反应的影响。在禁食大鼠后15分钟，记录了100和120 dB音调后的惊吓峰幅度，惊吓峰潜伏期和预脉冲抑制。在100-dB脉冲之后，安非他酮，阿托品，阿扎普芬，贝尼替嗪，双哌啶和东pol碱显着增加了峰值惊吓幅度，并减少了对峰值惊吓幅度的潜伏期。相比之下，在120 dB脉冲后，只有双倍肽增加了惊吓峰的振幅，而在120 dB脉冲后，阿托品和三己苯吡啶降低了对惊吓峰的潜伏期。 Benactyzine在100dB和120dB脉冲后均降低了前脉冲抑制，而Biperiden和scopolamine在120dB脉冲后均降低了前脉冲抑制。声音惊吓反应措施可有效区分抗胆碱能化合物的作用。比较药物对声音惊吓反应的作用可能有助于选择副作用最小的有效抗胆碱能药物疗法。此外，这些数据可能有助于减少涉及更复杂行为测试的比较研究中需要测试的抗胆碱能药物的数量。版权所有2001 John Wiley＆Sons，Ltd.

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