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首页> 外文期刊>Journal of applied toxicology >Concentrations of parabens in human breast tumours.
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Concentrations of parabens in human breast tumours.

机译：人乳腺肿瘤中对羟基苯甲酸酯的浓度。

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摘要

Parabens are used as preservatives in many thousands of cosmetic, food and pharmaceutical products to which the human population is exposed. Although recent reports of the oestrogenic properties of parabens have challenged current concepts of their toxicity in these consumer products, the question remains as to whether any of the parabens can accumulate intact in the body from the long-term, low-dose levels to which humans are exposed. Initial studies reported here show that parabens can be extracted from human breast tissue and detected by thin-layer chromatography. More detailed studies enabled identification and measurement of mean concentrations of individual parabens in samples of 20 human breast tumours by high-pressure liquid chromatography followed by tandem mass spectrometry. The mean concentration of parabens in these 20 human breast tumours was found to be 20.6 +/- 4.2 ng x g(-1) tissue. Comparison of individual parabens showed that methylparaben was present at the highest level (with a meanvalue of 12.8 +/- 2.2 ng x g(-1) tissue) and represents 62% of the total paraben recovered in the extractions. These studies demonstrate that parabens can be found intact in the human breast and this should open the way technically for more detailed information to be obtained on body burdens of parabens and in particular whether body burdens are different in cancer from those in normal tissues.
机译：对羟基苯甲酸酯在人类所接触的数千种化妆品，食品和药品中用作防腐剂。尽管最近有关对羟基苯甲酸酯的雌激素特性的报道已经挑战了其在这些消费产品中的毒性的当前概念，但是仍然存在一个问题，即对羟基苯甲酸酯是否可以从人体长期，低剂量的体内积累完整被暴露。此处报道的初步研究表明，对羟基苯甲酸酯可从人的乳房组织中提取并通过薄层色谱法检测。通过更详细的研究，可以通过高压液相色谱-串联质谱法鉴定和测量20种人乳腺肿瘤样品中各个对羟基苯甲酸酯的平均浓度。发现这20个人类乳腺肿瘤中对羟基苯甲酸酯的平均浓度为20.6 +/- 4.2 ng x g（-1）组织。各个对羟基苯甲酸酯的比较表明，对羟基苯甲酸甲酯的含量最高（平均值为12.8 +/- 2.2 ng x g（-1）组织），占提取物中回收的对羟基苯甲酸酯总量的62％。这些研究表明，在人的乳房中可以发现完整的对羟基苯甲酸酯，这应该从技术上为获取有关对羟基苯甲酸酯的身体负担，特别是癌症与正常组织的身体负担是否有所不同的详细信息开辟道路。

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