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首页> 外文期刊>Journal of applied toxicology >Responses of fish chromatophore-based cytosensor to a broad range of biological agents.
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Responses of fish chromatophore-based cytosensor to a broad range of biological agents.

机译：基于鱼染色体的细胞传感器对多种生物制剂的响应。

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摘要

A cytosensor based on living chromatophores from Betta splendens Siamese fi ghting fi sh was used to test several classes of biologically active agents. Tested agents include neurotransmitters, adenyl cyclase activators, cytoskeleton effectors, cell membrane effectors and protein synthesis inhibitors. Characteristic cell responses were analyzed, and potential cytosensor applications were considered. Streptococcus pyogenes toxins streptolysin S and streptolysin O, Clostridium tetani tetanolysin, Staphylococcus aureus alpha-toxin and Vibrio parahemolyticus hemolysin, all bacterial toxins that act on cell membranes, elicited a strong response from chromatophores. A comparison of puri fi ed toxin to actual bacterial culture from Vibrio parahemolyticus demonstrated a nearly identical chromatophore cell response pattern. This suggests that the cytosensor response is re fl ective of bacterial toxin production. Copyright (c) 2004 John Wiley & Sons, Ltd.
机译：基于来自Betta splendens Siamese figting fish的活体色谱的细胞传感器用于测试几类生物活性剂。被测试的试剂包括神经递质，腺苷酸环化酶激活剂，细胞骨架效应子，细胞膜效应子和蛋白质合成抑制剂。分析了特征性细胞反应，并考虑了潜在的细胞传感器应用。化脓性链球菌毒素，链球菌溶血素S和链球菌溶血素O，破伤风梭菌破伤风溶血素，金黄色葡萄球菌α毒素和副溶血弧菌溶血性溶血素，所有作用于细胞膜的细菌毒素，均会引起色谱强烈反应。将纯化的毒素与副溶血弧菌的实际细菌培养物进行比较，结果显示出几乎相同的色谱细胞反应模式。这表明细胞传感器反应与细菌毒素产生有关。版权所有（c）2004 John Wiley＆Sons，Ltd.

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